Talks：	The impact of different criteria in SDB diagnosis
Name：	莊立邦
Position：	Attending Physician, Assistant Professor
Affiliation：	1.Department of Thoracic Medicine, Department of Sleep Center, Chang Gung Memorial Hospital, Linkou, Taiwan 2.Department of Internal Medicine, Chang Gung University, Taoyuan, Taiwan
Email：	lpchuang1678@yahoo.com.tw
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Research Interests：	Epidemiology and Gender Difference of Sleep Disordered Breathing、 Intermittent Hypoxia Cell Model and Animal Model、 Pulmonary and Critical Care Medicine
Selected Publications：	◆Chuang LP, Lin SW, Lee LA, Li HY, Chang CH, Kao KC, Li LF, Huang CC, Yang CT, Chen NH* (2016, Dec). The gender difference of snore prevalence and increased tendency of snore in women with menopausal syndrome: a general population study. Sleep Breath. (Accepted). (SCI). ◆Chiu HY*, Chen PY, Chuang LP, Chen NH, Tu YK, Hsieh YJ, Wang YC, Guilleminault C (2016, Nov). Diagnostic Accuracy of the Berlin Questionnaire, STOP-Bang, STOP, and Epworth Sleepiness Scale in Detecting Obstructive Sleep Apnea: A Bivariate Meta-analysis. Sleep Medicine Reviews, pii: S1087-0792(16)30127-7. (SCI). ◆Chang CH, Chuang LP, Lin SW, Lee CS, Tsai YH, Wei YF, Cheng SL, Hsu JY, Kuo PH, Yu CJ, Chen NH* (2016, Aug). Factors responsible for poor sleep quality in patients with chronic obstructive pulmonary disease. BMC Pulm Med, 16(1):118. (SCI). ◆Lin YS, Liu PH, Lin SW, Chuang LP, Ho WJ, Chou YT, Juan KC, Lo MT, Chu PH, Chen NH* (2016, Jul). Simple obstructive sleep apnea patients without hypertension or diabetes accelerate kidney dysfunction: a population follow-up cohort study from Taiwan. Sleep Breath, Jul 5. (SCI). ◆Chen NH*, Chou YT, Lee PH, Lin SW, Chuang LP, Lin YS, Yang CT (2016, Jun). Reversibility of albuminuria and continuous positive airway pressure compliance in patients of obstructive sleep apnea syndrome. Medicine (Baltimore), 95(26):e4045. (SCI). ◆Chuang LP, Chen NH, Lin Y, Ko WS, Pang JH* (2016, Mar). Increased MCP-1 gene expression in monocytes of severe OSA patients and under intermittent hypoxia. Sleep Breath, 20(1):425-33. (SCI). ◆Lim DC*, Brady DC, Po P, Chuang LP, Marcondes L, Kim EY, Keenan BT, Guo X, Maislin G, Galante RJ, Pack AI. (2015, Mar). Simulating Obstructive Sleep Apnea Patients' Oxygenation Characteristics into a Mouse Model of Cyclical Intermittent Hypoxia. J Appl Physiol (1985), 118(5):544-57. (SCI). ◆Chuang LP, Chen NH, Lin SW, Chang YL, Liao HR, Lin YS, Chao IJ, Lin Y, Pang JH* (2014, Nov). Increased C-C Chemokine Receptor 2 Gene Expression in Monocytes of Severe Obstructive Sleep Apnea Patients and under Intermittent Hypoxia. PLoS One, 2014 Nov 20;9(11):e113304. (SCI). ◆Chuang LP, Chen NH, Lin SW, MD; Chang YL, Chao IJ, Pang JH*. (2013, Aug). Increased matrix metalloproteinases-9 after sleep in plasma and in monocytes of obstructive sleep apnea patients. Life sciences., 2013;93:220-225. (SCI). ◆Chou YT, Lee PH, Yang CT, Lin CL, Veasey S, Chuang LP, Lin SW, Lin YS, Chen NH*. (2011, Feb). Obstructive Sleep Apnea: a Stand-alone Risk Factor for Chronic Kidney Disease. Nephrol Dial transplant., 0, 1-6.. (SCI). ◆Chou YT, Chuang LP, Li HY, Fu JY, Lin SW, Yang CT, Chen NH* (2010, Feb). Hyperlipidaemia in patients with sleep-related breathing disorders: Prevalence & risk factors. Indian J Med Res, 131,121-125. (SCI). ◆Chuang LP, Chen NH*, Li HY, Lin SW, Chou YT, Wang CJ, Liao YF, Tsa YH (2009, Feb). Dynamic Upper Airway Changes During Sleep in Patients with Obstructive Sleep Apnea Syndrome. Acta Otolaryngol, 129(12),1474-9. (SCI). ◆Chuang LP, Hsu SC, Lin SW, Ko WS, Chen NH*, Tsai YH (2008, Mar). Prevalence of Snoring and Witness Apnea in Taiwanese Adults. Chang Gung Med J, p.177-p.183.
Abstract：	OSA is characterized by repeated episodes of upper airway obstruction resulting in cessation (apnea) or reduction (hypopnea) in airflow during sleep. The apnea hypopnea index (AHI), a count of the number of apneas and hypopneas per hour of sleep, is the key measure used for case identification, for quantifying disease severity, and for defining disease prevalence in normal and clinical populations. The scoring of apnea has always been clear and has generated minimal disagreement since its description in 1965. In contrast, since the first description of hypopnea in 1988, multiple definitions have been used in clinical practice and research, with no clear consensus. Differences in hypopnea definition relate to the degree of airflow reduction and/or oxygen desaturation required and the requirement for associated EEG arousal. The variability in the adopted definitions of hypopnea affects the diagnosis of OSA and reduces the inter-laboratory agreement for the AHI. Therefore, this talk aims to assess the impact of the different proposed hypopnea definition on the AHI, and the diagnosis of OSA relative to the 1999 Chicago Criteria, 2007 AASM and 2012 AASM definitions.