Talks：	An Innovative Strategy to Relieve Hepatic Oxidative Damage Resulted from Chronic Sleep Deprivation: Utilizing Plasmon-Activated Water as a Natural Approach
Name：	張宏名
Position：	Professor and Director
Affiliation：	Department of Anatomy and Cell Biology School of Medicine College of Medicine Taipei Medical University
Email：	taiwanzoo@gmail.com
Photo：
Research Interests：	1. Experimental Neuroscience 2. Sleep Medicine 3. Ionic Image and Surface Nanotechnology 4. Electro-microscopy 5. Anti-oxidative Research 6. Pediatric and Neuronal Physical Therapy
Selected Publications：	(2011-Present) (*: Corresponding Author) ◆Wu, U.I., Mai, F.D., Sheu, J.N., Chen, L.Y., Liu, Y.T., Huang, H.C. and Chang, H.M.* (2011) Melatonin inhibits microglial activation, reduces pro-inflammatory cytokine levels, and rescues hippocampal neurons of adult rats with acute Klebsiella pneumoniae meningitis. ◆Lim, F.F., Tsao, T.F., Chang, H.M. and Sheu, J.N.* (2011) Multicystic dysplastic kidney disease presenting with a single large cyst in a fetus – Anatomical basis and radiological aspects. Pediatrics and Neonatology 52: 227-231. ◆Lim, F.F., Chang, H.M., Lue, K.H. and Sheu, J.N.* (2011) Pneumococcal pneumonia complicating purulent pericarditis in a previously healthy girl: a rare yet possible fatal complication in the antibiotic era. Pediatric Emergency Care 27: 751-753. ◆Sheu, J.N.*, Chang, H.M., Chen, S.M., Hung, T.W. and Lue, K.H. (2011) The role of procalcitonin for acute pyelonephritis and subsequent renal scarring in infants and young children. Journal of Urology 186: 2002-2008. ◆Hu, M.E., Lin, Y.C., Chang, H.M., Tyan, Y.S. and Lan, C.T.* (2012) Obstructive jaundice activates nitroxidergic neurons of the vago-vagal neural circuit that regulates the hepatobiliary system in rabbits. Cells Tissues Organs 195: 272-286. ◆Chen, C.Y., Tsao, T.F., Chang, H.M., Chen, S.L., Chen, S.M., Hung, T.W., Lue, K.H. and Sheu, J.N.* (2012) Bladder agenesis and bilateral ectopic ureters draining into the vagina in a female infant: demonstrated by MR imaging. Surgical and Radiologic Anatomy 34: 89-92. ◆Hsieh, M.H., Ho, S.C., Yeh, K.Y., Pawlak, C.R., Chang, H.M., Ho, Y.J.*, Lai, T.J. and Wu, F.Y. (2012) Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model. Pharmacology, Biochemistry and Behavior 102: 64-71. ◆Chang, H.M., Liao, W.C., Sheu, J.N., Chang, C.C., Lan, C.T. and Mai, F.D.* (2012) Sleep deprivation impairs Ca2+ expression in the hippocampus: Ionic imaging analysis for cognitive deficiency with TOF-SIMS. Microscopy and Microanalysis 18: 425-435. ◆Chu, W.Y., Tsao, T.F., Chen, S.L., Chang, H.M., Chen, S.M., Chen, C.Y., Lue, K.H. and Sheu, J.N.* (2012) A 12-year-old boy with an infected ectopic ureter presenting with acute appendicitis-like symptoms and acute scrotum. Scandinavian Journal of Urology and Nephrology 46: 208-211. ◆Liao, W.C., Chen, C.H., Liu, C.H., Huang, M.J., Chen, C.W., Hung, J.S., Chou, C.H., Chen, C.H., Che, M.I., Chang, H.M., Lan, C.T., Huang, H.C., Tseng, G.F., Shyu, M.K. and Huang, M.C.* (2012) Expression of GALNT2 in human extravillous trophoblasts and its suppressive role in trophoblast invasion. Placenta 33: 1005-1011. ◆Pan, H.H., Chang, H.M., Chen, S.M., Hung, T.W., Lue, K.H. and Sheu, J.N.* (2012) Life-threatening rhabdomyolysis induced by Streptococcus bovis sepsis in a 6-year-old girl presented to the pediatric emergency department. Pediatric Emergency Care 28: 469-471. ◆Chen, S.M., Chang, H.M., Hung, T.W., Chao, Y.H., Tsai, J.D., Lue, K.H. and Sheu, J.N.* (2013) Diagnostic performance of procalcitonin for hospitalised children with acute pyelonephritis presenting to the paediatric emergency department. Emergency Medicine Journal 30: 406-410. ◆Sheu, J.N., Liao, W.C., Wu, U.I., Shyu, L.Y., Mai, F.D., Chen, L.Y., Chen, M.J., Youn, S.C. and Chang, H.M.* (2013) Resveratrol suppresses calcium-mediated microglial activation and rescues hippocampal neurons of adult rats following acute bacterial meningitis. Comparative Immunology, Microbiology and Infectious Diseases 36: 137-148. ◆Chang, H.M., Shyu, M.K., Tseng, G.F., Liu, C.H., Chang, H.S., Lan, C.T., Hsu, W.M. and Liao, W.C.* (2013) Neuregulin facilitates nerve regeneration by speeding Schwann cell migration via erbB2/3-dependent FAK pathway. PLoS One 8: e53444. ◆Chang, H.M., Liu, C.H., Hsu, W.M., Chen, L.Y., Wang, H.P., Wu, T.H., Chen, K.Y., Ho, W.H. and Liao, W.C.* (2014) Proliferative effects of melatonin on Schwann cells: implication for nerve regeneration following peripheral nerve injury. Journal of Pineal Research 56: 322-332. ◆Hsu, C.Y., Hung, C.S., Chang, H.M., Liao, W.C., Ho, S.C. and Ho, Y.J.* (2015) Ceftriaxone prevents and reverses behavioral and neuronal deficits in an MPTP-induced animal model of Parkinson’s disease dementia. Neuropharmacology 91: 43-56. ◆Chen, L.Y., Tiong, C., Tsai, C.H., Liao, W.C., Yang, S.F., Youn, S.C., Mai, F.D. and Chang, H.M.* (2015) Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency. Brain Structure and Function 220: 663-676. ◆Liao, W.C., Liu, C.H., Chen, C.H., Hsu, W.M., Liao, Y.Y., Chang, H.M., Lan, C.T., Huang, M.C. and Shyu, M.K.* (2015) β-1,4-galactosyltransferase III suppresses extravillous trophoblast invasion through modifying β1-integrin glycosylation. Placenta 36: 357-364. ◆Kuo, Y.J., Huang, Y.K., Chou, H.C., Pai, M.H., Lee, A.W., Mai, F.D. and Chang, H.M.* (2015) Reduced dental calcium expression and dental mass in chronic sleep deprived rats: Combined EDS, TOF-SIMS, and micro-CT analysis. Applied Surface Science 345: 141-144. ◆Youn, S.C., Chen, L.Y., Chiou, R.J., Lai, T.J., Liao, W.C., Mai, F.D. and Chang, H.M.* (2015) Comprehensive application of time-of-flight secondary ion mass spectrometry (TOF-SIMS) for ionic imaging and bio-energetic analysis of club drug-induced cognitive deficiency. Scientific Reports 5: 18420. ◆Liu, C.H., Chang, H.M., Tseng, T.J., Lan, C.T., Chen, L.Y., Youn, S.C., Lee, J.J., Mai, F.D., Chou, J.F. and Liao, W.C.* (2016) Redistribution of Cav2.1 channels and calcium ions in nerve terminals following end-to-side neurorrhaphy: ionic imaging analysis by TOF-SIMS. Histochemistry and Cell Biology 146: 599-608.
Abstract：	The hepato-protective agent during chronic sleep deprivation (SD) is realized by using plasmon-activated water (PAW) as an innovative anti-oxidant strategy. The PAW possesses reduced hydrogen-bonded structure, higher chemical potential and significant anti-oxidative properties. In vitro tests to the rat liver cell line (Clone-9) are demonstrated that PAW is non-cytotoxic and does not change the cellular migration capacity. The in vivo experiment of SD rats involving in the damages of liver structure and function from intense oxidative damage, an extremely common phenomenon with deleterious effects on metabolic function in modern societies was performed by drinking PAW to replace deionized (DI) water. Experimental results indicated that PAW markedly reduced oxidative stress with enhanced bioenergetics in hepatocytes. PAW also effectively restored hepatocytic trans-membrane ion homeostasis, preserved membranous structures, and successfully improved liver function and metabolic activity. In addition, the hepato-protective effects of PAW were evidently demonstrated by reduced values of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) and recovery of total protein and albumin levels. With clear evidences of PAW for protecting liver from SD-induced injury, regular drinking of PAW should be worthy of trailblazing new clinical trials as a powerful hepato-protective agent in a healthier, more-natural, and more-convenient way.