Talks：

Animal Models of Circadian Desynchronization

Name：

蔡玲玲(Ling-Ling Tsai)

Position：

professor

Affiliation：

Department of Psychology, National Chung Cheng University

Email：

psyllt@ccu.edu.tw

Photo：

Research Interests：

Sleep and Error monitoring, Photic Effects on Sleep and Circadian Rhythms, Circadian Rhythm Disruption and Health

Selected Publications：

◆ 蕭帆琦、蔡玲玲。2017。中文版「日夜作息習慣量表」：紙本標準版與網路版。中華心理學刊59(4):197-212。[Hsiao, FC, Tsai LL. 2017. Chinese version of the Owl and Lark Questionnaire: Paper-pencil and internet administration. Chinese Journal of Psychology 59(4):197-212.] ◆ Ko CH, Fang YW, Tsai LL, Hsieh S. 2015. The effect of experimental sleep fragmentation on error monitoring. Biological Psychology 104:163-172. ◆ Hsiao F-C, Liao Y-H, Tsai LL. 2013. Differential effects of retinal degeneration on sleep and wakefulness responses to short light-dark cycles in albino mice. Neuroscience 248:459-468. ◆ Hsieh S, Li T-H, Tsai LL. 2010. Impact of monetary incentives on cognitive performance and error monitoring following sleep deprivation. Sleep 33(4): 499-507. Mishra A, Cheng CH, Lee WC, Tsai LL. 2009. Proteomic changes in the hypothalamus and retroperitoneal white adipose tissue from male F344 rats subjected to repeated light-dark shifts. Proteomics 9:4017-4028. ◆ Tsai LL, Tsai YC. 2007. The effect of scheduled forced wheel activity on body weight in male F344 rats undergoing chronic circadian desynchronization. International Journal of Obesity 31:1368-1377. ◆ Tsai LL, Tsai YC, Hwang K, Huang YW, Tzeng JE. 2005. Repeated light-dark shifts speed up body weight gain in male F344 rats. American Journal of Physiology-Endocrinology and Metabolism 289(2):E212-E217. ◆ Tsai LL, Li SP. 2004. Sleep patterns in college students: gender and grade differences. Journal of Psychosomatic Research 56(2):231-237.

Abstract：

Chronic disruptions of circadian rhythms, like jet lag or shift work, are associated with adverse metabolic changes, such as being overweight and impaired glucose metabolism. The causal relationship and its underlying mechanisms between work shifts and metabolic disturbances have been intensively studied using animal models of circadian desynchronization over the past decade. In this presentation, I will review two animal paradigms of circadian desynchronization, induced by genetic mutations in circadian clock genes and by experimental shifts of the phase of the time cue (Zeitgeber). The counteracting effect of exercise and modified food intake behavior on the adverse metabolic consequences of circadian desynchronization will also be discussed.