Talks：

The association between sleep apnea and cancer

Name：

蔡明儒(Ming-Ju Tsai, M.D., Ph.D.)

Position：

Attending Physician and Assistant Professor

Affiliation：

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, and Department of Internal Medicine, School of Medicine, Kaohsiung Medical University

Email：

SiegfriedTsai@gmail.com

Photo：

Research Interests：

Sleep apnea and other sleep-disordered breathing Chronic airway diseases (asthma, chronic obstructive pulmonary disease, …) Lung cancer

Selected Publications：

◆ Tsai MJ, Hsu YL, Wang TN, Wu LY, Lien CT, Hung CH, Kuo PL, Huang MS. Aryl hydrocarbon receptor (AhR) agonists increase airway epithelial matrix metalloproteinase activity. J Mol Med (Berl) 2014;92:615-28. ◆ Tsai MJ, Yang CJ, Kung YT, Sheu CC, Shen YT, Chang PY, Huang MS, Chiu HC. Metformin decreases lung cancer risk in diabetic patients in a dose-dependent manner. Lung Cancer 2014;86:137-43. ◆ Wu KL#, Tsai MJ#, Yang CJ, Chang WA, Hung JY, Yen CJ, Shen CH, Kuo TY, Lee JY, Chou SH, Liu TC, Chong IW, Huang MS. Liver metastasis predicts poorer prognosis in stage IV lung adenocarcinoma patients receiving first-line gefitinib. Lung Cancer 2015;88:187-94. ◆ Tsai MJ, Wang TN, Lin YS, Kuo PL, Hsu YL, Huang MS. Aryl hydrocarbon receptor agonists upregulate VEGF secretion from bronchial epithelial cells. J Mol Med (Berl) 2015;93:1257-69. ◆ Chen CM#, Tsai MJ#, Wei PJ#, Su YC, Yang CJ, Wu MN, Hsu CY, Hwang SJ, Chong IW, Huang MS. Erectile Dysfunction in Patients with Sleep Apnea--A Nationwide Population-Based Study. PLoS One 2015;10:e0132510. ◆ Tsai MJ, Wu PH, Sheu CC, Hsu YL, Chang WA, Hung JY, Yang CJ, Yang YH, Kuo PL, Huang MS. Cysteinyl Leukotriene Receptor Antagonists Decrease Cancer Risk in Asthma Patients. Sci Rep 2016;6:23979. ◆ Tsai MJ, Chang WA, Tsai PH, Wu CY, Ho YW, Yen MC, Lin YS, Kuo PL, Hsu YL. Montelukast Induces Apoptosis-Inducing Factor-Mediated Cell Death of Lung Cancer Cells. Int J Mol Sci 2017;18:1353.

Abstract：

Sleep apnea is the most common form of sleep disordered breathing characterized by recurrent cessation of breathing during sleep, usually associated with intermittent hypoxia and sleep fragmentation. Some in vivo and in vitro studies have shown that intermittent hypoxia might enhance cancer progression and metastasis. Although the detailed pathophysiological mechanisms require further investigation, the association between sleep apnea and cancer have been found in some cohort studies. In a study of Wisconsin Sleep Cohort, baseline sleep-disordered breathing was associated with increased cancer mortality. Another clinical study from the Spanish Sleep Network also demonstrated an increased cancer incidence in patients having higher percent nighttime with desaturation than in those having lower percent nighttime with desaturation, whereas patients with higher apnea-hypopnea index (AHI) did not have higher cancer incidence than those with lower AHI. Another study using Truven Health MarketScan Research Databases, an insurance database in the USA, found a higher risk of pancreatic and kidney cancers and melanoma in sleep apnea patients, whereas the risks of colorectal, breast, and prostate cancers were lower in sleep apnea patients. The findings suggested that the associations between sleep apnea and cancer might be different in various types of cancers. Further prospective studies are therefore critically needed to clarify the impact of histological types and organ location of cancer, as well as the treatment for sleep apnea, on the association between sleep apnea and cancer.