◆ Liu HW, Chen YJ, Lai YC, Huang CY, Huang YL, Lin MT, Han SY, Chen CL, Yu CJ, Lee PL. (2017, Oct). Combining MAD and CPAP as an effective strategy for treating patients with severe sleep apnea intolerant to high-pressure PAP and unresponsive to MAD. PLoS One, 12(10):e0187032.
◆ Yeh KY, Yeh CC, Wu CC, Tang K, Wu JY, Chen YT, Xu MX, Chen YJ, Yang YJ, Lu SS. (2017, Oct). A Wireless Monitoring System Using a Tunneling Sensor Array in a Smart Oral Appliance for Sleep Apnea Treatment. Sensors, 17,2358;doi:10.3390/s17102358. MOST 105-2221-E-002-216
◆ Huon LK, Liu SY, Shih TT, Chen YJ, Lo MT, Wang PC (2016, Dec). Dynamic upper airway collapse observed from sleep MRI: BMI-matched severe and mild OSA patients. Eur Arc Otorhinolaryngol, 273(11):4021-4026.
◆ Yunn-Jy Chen, Tiffany Ting-Fang Shih, Yi-Chung Chang, Ying-Chieh Hsu, LehKiong Huon, Men-Tzung Lo, Van-Truong Pham, Chen Lin, Pa-Chun Wang (2015, Dec). Acoustic-integrated dynamic MR imaging for a patient with obstructive sleep apnea. Magnetic Resonance Imaging, 33, 1350-1352
◆ Yi-Chung Chang, Leh-Klng Huon, Van-Truong Pham, Yunn-Jy Chen, Sun-Fen Jiang, Tiffany Ting-Fang Shih Thi-Thao Tran, Yung-Hung Wang, Chen Lin, Henho Tsao, Men-Tzung Lo, Pa-Chun Wang (2014, Dec). Synchronized imaging and acoustic analysis of the upper airway in patients with sleep-disordered breathing. Physiological Measurement, 35,2501-2512
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Since sleep disordered breathing (SDB) is a multifactorial disease, it’s hard to find a universal treatment for all patients. Therefore, combining different treatments might be a good strategy. In order to develop possible combination strategies, we have to investigate the mechanisms, advantages, and limitations of different treatment modalities.
Regarding to the mandible advancing device (MAD):
1.MAD can widen the lateral pharyngeal walls of the upper airway. But its effects are often compromised in obese patients or patients needs high CPAP pressure.
2.The tongue won’t be necessarily pulled forwards within the MAD. However, with certain designs, the MAD might be able to assist in supporting the tongue.
3.For patients with small tongue volume and low level of hyoid bone, the behaviors of the tongue within the MAD is hard to predict.
Thus, the MAD might play certain roles in combining with other treatments:
1.We have demonstrated the combination of MAD and CPAP can effectively lower the CPAP pressure.
2.For MAD users with residual snoring, MAD might prevent/delay the relapse of soft tissue surgeries.
3.Combing MAD and tongue-suspension surgery might be helpful in treating SDB patients with small and low-positioned tongue.
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