Talks：

Integrated treatment for OSA-from anatomy, physiology to psychology – CPAP and Beyond

Name：

邱國樑（Kuo-Liang Chiu, MD）

Position：

Secretary of Medical Affair and Director of Sleep Medicine Center, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

Affiliation：

Assistant Professor, School of Medicine, Tzu Chi University,

Email：

kuoliang.chiu@gmail.com; klchiu@tzuchi.com,tw

Photo：

Research Interests：

Cardiopulmonary interaction and complication of Sleep disordered breathing. Lung cancer.

Selected Publications：

◆ Chiu KL, Lin YS, Kuo TT, Lo CC, Huang YK, Chang HF, Chuang EY, Lin CC, Cheng WC, Liu YN, Lai LC, Sher YP. ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis. Oncotarget. 2017 Jul 18;8(29):47365-47378. ◆ Chiu KL, Kuo TT, Kuok QY, Lin YS, Hua CH, Lin CY, Su PY, Lai LC, Sher YP. ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis. Sci Rep. 2015 Nov 10;5:16426. ◆ Su MC, Chiu KL, Ruttanaumpawan P, Shiota S, Yumino D, Redolfi S, Haight JS, Yau B, Lam J, Bradley TD. Difference in upper airway collapsibility during wakefulness between men and women in response to lower-body positive pressure. Clin Sci (Lond). 2009 May;116(9):713-20 ◆ Su MC, Chiu KL, Ruttanaumpawan P, Shiota S, Yumino D, Redolfi S, Haight JS, Bradley TD. Lower body positive pressure increases upper airway collapsibility in healthy subjects. Respir Physiol Neurobiol. 2008 May 31;161(3):306-12 ◆ Chiu KL, Ryan CM, Shiota S, Ruttanaumpawan P, Arzt M, Haight JS, Chan CT, Floras JS, Bradley TD. Fluid shift by lower body positive pressure increases pharyngeal resistance in healthy subjects. Am J Respir Crit Care Med. 2006 Dec 15;174(12):1378-83

Abstract：

Obstructive sleep apnea (OSA) is a common sleep-disordered breathing, which is associated with many cardiovascular and metabolic consequences. Continuous positive airway pressure (CPAP) is the treatment of choice for OSA. Therefore, the adherence of CPAP therapy is critical in treatment of OSA. Previous studies suggest the rate of CPAP use in patients of OSA varies from 30-60%. The factors influencing the adherence include patient characteristics, disease characteristics, technological factors, initial CPAP exposure factors, and psychosocial factors. There are many interventions shown to be helpful to improve CPAP adherence. However, despite of aggressive intervention, there are still a significant number of patients who could not tolerate to CPAP therapy. In this talk, we will discuss how to improve the adherence of CPAP therapy and the multimodalities treatment strategy when CPAP alone fails.