Talks：

Nocturnal SOREMPs as a Predictor of the Severity of Narcolepsy in Korea

Name：

JiHye Oh

Position：

Clinical fellow

Affiliation：

St. Vincent’s Hospital

Email：

Photo：

Research Interests：

Narcolepsy, Insomnia disorder, Cognitive and Behavioral Therapy (CBT) for sleep disorders

Selected Publications：

The Reliability and Validity of the Korean Version of Behavioral Activation for Depression Scale J Korean Neuropsychiatry Assoc. 2017 May;56(2):89-97. Korean.

Abstract：

Study Objectives: The aim of this study is to investigate the severity of narcolepsy based on the presence of nocturnal sleep onset rapid eye movement sleep period (nSOREMP). Methods: Subjects included 167 narcolepsy patients diagnosed at the St. Vincent Hospital, the Catholic University of Korea. They underwent polysomnography (PSG) and Multiple Sleep Latency Test (MSLT). The standardized face to face interview and Epworth Sleepiness Scale were used to inquire about daytime sleepiness of the patients. Overall retrospective chart review was performed on their sleep health data. Results: The presence of nSOREMP was highly correlated with short mean sleep latency and high number of SOREMPs in MSLT. Subjects with nSOREMP also demonstrated higher percentage of N1 sleep, lower percentage of N2 sleep, and more frequent arousals in PSG. Also, they showed higher prevalence of cataplexy and HLA DQB1*0602 positivity. Conclusions: The subjects with nSOREMP showed more excessive daytime sleepiness and lower quality of sleep compared to the subjects without nSOREMP. Our study thereby suggests that nSOREMP possibly be the severity marker of narcolepsy. Keywords: Multiple Sleep Latency Test, nocturnal Sleep Onset Rapid Eye Movement Sleep Period, nocturnal polysomnography, narcolepsy, cataplexy,