講師資料
Talks：
Central sleep apnea in patients with heart failure
Name：
莊立邦(Li-Pang Chuang)
Position：
Chief1, Attending Physician2, Assistant Professor3
Affiliation：
1.Department of Sleep Center, Chang Gung Memorial Hospital, Linkou, Taiwan
2.Department of Thoracic Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan
3.Department of Medicine, Chang Gung University, Taoyuan, Taiwan
Email：
Photo：
Research Interests：
Sleep Disordered Breathing
Intermittent Hypoxia Cell Model and Animal Model
Selected Publications：
1. Chuang LP, Hsu SC, Lin SW, Ko WS, Chen NH*, Tsai YH. Prevalence of Snoring and Witness Apnea in Taiwanese Adults. Chang Gung Med J 2008;31:177-83
2. Chuang LP, Chen NH*, Li HY, Lin SW, Chou YT, Wang CJ, Liao YF, Tsa YH. Dynamic Upper Airway Changes During Sleep in Patients with Obstructive Sleep Apnea Syndrome. Acta Otolaryngol 2009 Dec;129(12):1474-9（SCI）
3. Chuang LP, Chen NH, Lin SW, MD; Chang YL, Chao IJ, Pang JH*. Increased matrix metalloproteinases-9 after sleep in plasma and in monocytes of obstructive sleep apnea patients. Life sciences. 2013;93:220-225 (SCI）
4. Chuang LP, Chen NH, Lin SW, Chang YL, Liao HR, Lin YS, Chao IJ, Lin Y, Pang JH*. Increased C-C Chemokine Receptor 2 Gene Expression in Monocytes of Severe Obstructive Sleep Apnea Patients and under Intermittent Hypoxia. PLoS One. 2014 Nov 20;9(11):e113304. (SCI）
5. Chuang LP, Chen NH, Lin Y, Ko WS, Pang JH*. Increased MCP-1 gene expression in monocytes of severe OSA patients and under intermittent hypoxia. Sleep Breath. 2016 Mar;20(1):425-33. (SCI)
6. Chuang LP, Lin SW, Lee LA, Li HY, Chang CH, Kao KC, Li LF, Huang CC, Yang CT, Chen NH*. The gender difference of snore prevalence and increased tendency of snore in women with menopausal syndrome: a general population study. Sleep Breath. 2017 May;21(2):543-547. (SCI)
7. Chuang LP, Lin SW, Lee LA, Chang CH, Huang HY, Hu HC, Kao KC, Hsieh MJ, Yang CT, Li HY, Chen NH*. (2019, Feb). Elevated Serum Markers of Acute Kidney Injury in Patients with Obstructive Sleep Apnea. Journal of Clinical Sleep Medicine, 15(2):207-213. (SCI). MOST 106-2314-B-182A-073.
8. Chuang LP, Chen NH, Lin SW, Hu HC, Kao KC, Li LF, Yang CT, Huang CC, Pang JS*. (2019, Feb). Monocytic C-C chemokine receptor 5 expression increases in in vitro intermittent hypoxia condition and in severe obstructive sleep apnea patients. Sleep Breath, Feb 18. pii: 10.1007/s11325-019-01797-4. doi: 10.1007/s11325-019-01797-4.(SCI)
9. Chuang LP; Hsieh MJ; Chen NH; Hu HC; Yang CT; Tsai YH; Lin SW*. Total Sleep Time in the Taiwan Obstructive Lung Disease Cohort. Int J Environ Res Public Health. 2021 Jul 2;18(13).
10. Chuang LP, Wu HP, Lee LA, Chiu LC, Lin SW, Hu HC, Kao KC, Chen NH, Tsai JW, Pang JH* (2021, Oct). Elevated Monocytic Interleukin-8 Expression under Intermittent Hypoxia Condition and in Obstructive Sleep Apnea Patients. International Journal of Molecular Sciences, 2021, 22(21), 11396; https://doi.org/10.3390/ijms222111396.
11. Chuang LP, Pang JS, Lin SW, Hung KC, Hu HC, Kao KC, Wen MS, Chen NH. (2022, Jan). Elevated serum matrix metalloproteinase-2 levels in heart failure patients with reduced ejection fraction and Cheyne-Stokes respiration. J Clin Sleep Med, 2022 May 1;18(5):1365-1373. doi: 10.5664/jcsm.9870.
Abstract：
對比阻塞型睡眠呼吸中止症，中樞型睡眠呼吸中止(CSA)一般較少見；比較為人熟知的原因包括某些藥物引起，如鴉片類藥物, 心臟衰竭, 以及大腦的疾病或傷害, 例如中風、腦瘤等等。 在CSA發生的情況下，呼吸道實際上並沒有阻塞, 但是因為沒有呼吸驅力所以空氣停止流向肺部。這主要是因為大腦和身體之間的溝通出了問題, 所以呼吸的動作停止了。那些有 CSA 的人並不經常打鼾, 所以這種情況有時會被忽視。值得注意的是，在心臟衰竭的情況下，CSA是非常頻繁的, 超過 1/4 的患者會被影響，特別是左心射出分壓低的心臟衰竭病患。CSA在心臟衰竭的病人身上有一個特別的呼吸模式，被稱為陳施氏呼吸(CSR)。這是一個不正常、在加快的呼吸及暫停的呼吸之間形成一個迴圈式的呼吸模式。 本次的演講主要著重在探討心衰竭病患的中樞型呼吸中止症之關連性、致病機轉及可能的治療方法。並且也深入到其相關的生物指標(bio-makers)及應用。