1. Rikitake Y, Oyama N, Wang CY, Noma K, Satoh M, Kim HH, Liao JK*. Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1 +/- haploinsufficient mice. Circulation. 2005 Nov 8; 112(19):2959-2965
2. Satoh M, Matter CM, Ogita H, Takeshita K, Wang CY, Dorn GW, Liao JK*. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation. 2007 Jun 26; 115(25):3197-3204.
3. Wang CY, Wen MS, Wang HW, Hsieh IC, Li Y, Liu PY, Lin FC, Liao JK*. Increased vascular senescence and impaired angiogenesis in mice with mutation of the circadian gene Per2. Circulation. 2008 Nov 18; 118(21):2166-2173.
4. Wang CY, Kim HH, Hiroi Y, Sawada N, Salomone S, Benjamin LE, Walsh K, Moskowitz MA, Liao JK*. Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Science Signaling. 2009 Mar 17; 2(62):Ra11.
5. Wang CY*, Shie SS, Wen MS, Hung KC, Hsieh IC, Yeh TS, Wu D. Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism. Science Signaling. 2015 Dec 15; 8(407):ra127.
6. Ho MY*, Yeh JK, Wang CY, Hsieh IC. Aortic Dissection With Severe Aortic Regurgitation. Circulation. 2016 Feb 16; 133(7):e398-9.
7. Lin YS, Tsai ML, Hsieh IC, Wen MS, Wang CY*. Deficiency of circadian gene cryptochromes in bone marrow-derived cells protects against atherosclerosis in LDLR -/- mice. FASEB J. 2021 Feb;35(2): e21309.
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The day and night cycle is based on the rotation of the Earth on its axis. The circadian rhythm, driven by molecular clocks and external cues, connects the environmental changes to endogenous physiological function, behavior activities, and organ homeostasis, including the cardiovascular system. Disrupting the circadian rhythm due to shift work, long-distance traveling, or genetic variations can lead to obesity, aging, and atherosclerosis.
Experimental evidence and clinical trials both suggest that circadian rhythm disruption results in disruption of cardiovascular physiology and malalignment of multiple cellular functions. Genetic deletion of several circadian genes or shift works all result in increased cardiovascular disease incidences, worsening outcomes, and higher mortality. The interactions of circadian rhythm and the cardiovascular system are comprehensive, including atherosclerosis, endothelial function, heart failure, arrhythmia, and blood pressure control. In this talk, we will examine the detailed links between circadian rhythm and cardiovascular diseases.
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