講師資料
Talks：
The role of neurogenic inflammation in obstructive sleep apnea
Name：
劉文德(Wen-Te Liu)
Position：
1. Director, Sleep Center of Shuang Ho Hospital, Taipei Medical University
2. Associate Professor, School of Respiratory Therapy, College of Medicine, Taipei Medical University
3. Director, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University
4. Attending Physician, Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University
Affiliation：
1. School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 11052, Taiwan.
2. Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Email：
Photo：
Research Interests：
Sleep medicine, Obstructive sleep apnea, Artificial intelligence in medicine, pulmonary medicine
Selected Publications：
1. Hsu YS, Chen TY, Wu D, Lin CM, Juang JN, Liu WT. Screening of Obstructive Sleep Apnea in Snoring Patients Using a Patch-Type Device With Electrocardiogram and 3-Axis Accelerometer. Journal of Clinical Sleep Medicine. 2020 Jul 15, 16(7):1149-1160, DOI: 10.5664/jcsm.8462
2. Lo K, Chiang LL, Hsu SM, Tsai CY, Wu D, Chou CJ, Chuang CH, Liu WT. Association of Short-term Exposure to air pollution with depression in patients with sleep-related breathing disorders. Science of The Total Environment. 2021. 147291ISSN 0048-9697.
3. Liu WT, Lin SY, Tsai CY, Liu YS, Hsu WH, Majumdar A, Lin CM, Lee KY, Wu D, Kuan YC, Lee HC, Wu CJ, Cheng WH, Hsu YS. Comparison of Hospital-Based and Home-Based Obstructive Sleep Apnoea Severity Measurements with a Single-Lead Electrocardiogram Patch. Sensors (Basel). 2021 Dec 3;21(23):8097. doi: 10.3390/s21238097. PMID: 34884101; PMCID: PMC8659975.
Abstract：
As we know, craniofacial abnormality and obesity, the kind of anatomical factors, are essential to cause obstructive sleep apnea (OSA). However, studies have also found that chronic rhinitis, sinusitis, and gastroesophageal reflux, are also prone to inflammation of the upper airway leading to congestion and swelling to deteriorate the severity of OSA. In recent years, research on gastroesophageal reflux disease (GERD) and non-allergic rhinitis found associations between some cellular receptors and these disorders. Activating one of the cellular receptors, transient receptor potential cation channel, subfamily V, member 1 (TRPV1) will cause an inflammatory response of the upper airway and esophagus, which is a phenomenon of neurogenic inflammation. The patients will develop symptoms such as runny nose, cough, and acid regurgitation that also cause the deterioration of OSA. Some evidence suggests that patients with erosive esophagitis had increased mRNA performance of TRPV1 on their esophageal mucosa. Besides, the severity of related respiratory inflammation and gastroesophageal reflux will improve if treated with an antagonist against TRPV1. Therefore, these clinical features of GERD, rhinitis and the associated upper airway inflammation are neurogenic inflammation, which is an essential factor leading to OSA. We need further research to approach the role of neurogenic inflammation in the upper airway to figure out the pathogenesis and other treatment strategies.