講師資料
Talks：
Sleep-Heart Interaction: Heart Failure
Name：
吳彥雯(Yen-Wen Wu)
Position：
Director
Affiliation：
Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Email：
Photo：
Research Interests：
Internal Medicine, Cardiology, Nuclear Medicine, Cardiovascular Functional Imaging, Atherosclerosis, Heart Failure, Biomarkers
Selected Publications：
First or corresponding author*/Original Articles (2018-2022)
1. Cheng MF, Guo YL, Yen RF, Chen YC, Ko CL, Tien YW, Laio WC, Liu CJ, Wu YW*, Wang HP. Clinical Utility of FDG PET/CT in patients with autoimmune pancreatitis: a case-control study. Sci Rep. 2018 Feb 26;8(1):3651.
2. Tsai SY, Wang SY, Shiau YC, Wu YW*. Mechanical dyssynchrony and diastolic dysfunction are common in patients with left ventricular hypertrophy: a pilot correlation study using Doppler echocardiography and CZT gated-SPECT MPI. Sci Rep. 2018 Mar 8;8(1):4182
3. Ho SK, Wu YW*, Tseng WK, Leu HB, Yin WH, Lin TH, Chang KC, Wang JH, Yeh HI, Wu CC, Chen JW. The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease. Sci Rep 2018 Sep 26;8(1):14410.
4. Liu FS, Wang SY, Shiau YC, Wu YW*. The clinical value and safety of ECG-gated dipyridamole myocardial perfusion imaging in patients with aortic stenosis. Sci Rep. 2019 Aug 27;9(1):12443.
5. Huang JY, Yen RF, Lee WC, Huang CK, Hsu PY, Chien KL, Wu YW*. Improved diagnostic accuracy of myocardial perfusion single-photon emission computed tomography with CT attenuation correction. J Nucl Cardiol. 2019 Oct;26(5):1584-95.
6. Tsai SY, Wu YW*, Wang SY, Shiau YC, Chiu KM, Tsai HY, Lee CL, Hsu JC, Tu CM, Lin HH, Huang SH. Clinical significance of quantitative assessment of right ventricular glucose metabolism in patients with heart failure with reduced ejection fraction. Eur J Nucl Med Mol Imaging. 2019 Nov; 46(12): 2601-9.
7. Ko KY, Wang SY, Yen RF, Shiau YC, Hsu JC, Tsai HY, Lee CL, Chiu KM, Wu YW*. Clinical significance of quantitative assessment of glucose utilization in patients with ischemic cardiomyopathy. J Nucl Cardiol. 2020 Feb;27(1):269-79.
8. Lin WL, Wang SY, Shiau YC, Wu YW*. The clinical usefulness of phase analysis in detecting coronary artery disease using dipyridamole thallium-201-gated myocardial perfusion imaging with a cadmium-zinc-telluride camera. J Nucl Cardiol. 2020 Feb;27(1):241-50.
9. Wu YW, Ho SK, Tseng WK, Yeh HI, Leu HB, Yin WH, Lin TH, Chang KC, Wang JH, Wu CC, Chen JW. The prognostic value of serum high-sensitivity creatine kinase-MB in patients with stable coronary heart disease. Sci Rep. 2020 Mar 27;10(1):5638.
10. Liu CW, Chen JH, Tseng GS, Chen KH, Hwang JJ, Yang WS. Wu YW*. Association between low-grade inflammation and left ventricular diastolic dysfunction in patients with metabolic syndrome and hyperuricemia. Acta Cardiol Sin. 2020. Sep;36(5):483-92.
11. Wu YW, Chang TT, Chien CC, Chen JW. Fatty-acid-binding protein 4 as a novel contributor to mononuclear cell activation and endothelial cell dysfunction in clinical atherosclerosis. Int J Mol Sci. 2020 Dec 3;21(23):9245.
12. Tsai HY, Wu YW*, Tseng WK, Leu HB, Yin WH, Lin TH, Chang KC, Wang JH, Yeh HI, Wu CC, Chen JW. Circulating fatty acid binding protein 4 levels predict CV events in patients after coronary interventions. J Formos Med Assoc. 2021;120:728-36.
13. Huang YH, Lin YH, Yen RF, Hou CJ, Wang SY, Tsai SC, Ho KC, Lin MH, Tsao CH, Chang CY, Huang JL, Cheng MF, Wu YW*. 2021 Advocacy statements for the role of 99mTc-pyrophosphate scintigraphy in the diagnosis of transthyretin cardiac amyloidosis: a report of the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China. Acta Cardiol Sin. 2021 May;37(3):221-31.
14. Huang JY, Huang CK, Yen RF, Chien KL, Wu YW*. Diagnostic effect of attenuation correction in myocardial perfusion imaging in different coronary arteries: a systematic review and meta-analysis. Front. Cardiovasc. Med. 2021;8:756060.
15. Huang JY, Yen RF, Huang CK, Liu CJ, Cheng MF, Chien KL, Wu YW*. Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study. PLoS One. 2021 Oct 26;16(10):e0258983.
16. Lu LS, Wu YW (equally contributed), Chang JTC, Chang WT, Chao TH, Chen HHW, Chen YJ, Cheng KH, Hsu WL, Hung CL, Kuo SH, Liang JA, Lin HJ, Liu PY, Liu WS, Liu YW, Shueng PW, Wang CY, Hou CJY, Chiou JF, TASTRO-TSOC Cardio-Oncology Task Force. Risk management for radiation-induced cardiovascular disease (RICVD): The 2022 consensus statement of the Taiwan Society for Therapeutic Radiology and Oncology (TASTRO) and Taiwan Society of Cardiology (TSOC). Acta Cardiol Sin 2022;38:1-12.
17. Chung CS, Chen CC, Chen KC, Fang YJ, Hsu WF, Chen YN, Tseng WC, Lin CK, Lee TH, Wang HP, Wu YW*. Randomized controlled trial of early endoscopy for upper gastrointestinal bleeding in acute coronary syndrome patients. Sci Rep. 2022 Apr 6;12(1):5798.
18. Liu FS, Wang SY, Shiau YC, Wu YW*. Integration of quantitative absolute myocardial blood flow estimates from dynamic CZT-SPECT improves the detection of coronary artery disease. J Nucl Cardiol. 2021 Jul 8. doi: 10.1007/s12350-021-02713-8. Online ahead of print.
Abstract：
Sleep-disordered breathing (SDB), including obstructive sleep apnea, central sleep apnea (CSA), and Cheyne-Stokes respiration, is common in patients with heart failure (HF) and associated with lower left ventricular ejection fraction (LVEF), increased arrhythmia burden, and increased mortality. All HF patients should be screened for SDB. Effective treatment of OSA with continuous positive airway pressure (CPAP) therapy improves short-term and long-term outcomes in HF patients. Although adaptive servoventilation (ASV) appears to not reduce CV and all-cause death for HF patients with extremely low LVEF, those with profound CSA associated hypoxemia or less severe HF still benefit from ASV therapy. In this talk, we outline the current understanding of the bidirectional relationship between these disorders and HF. Although limited evidence, some studies have shown that sleep quality and insomnia are associated with cognitive function, and patients with HF that are at high risk for cognitive decline. In this talk, we also explore emerging data on the cost effectiveness and outcome of intervention and recent advances in therapeutics, including ongoing trials.