講師資料
Talks：
New era in Microbiota Technology
Name：
周士軒（Shih-Hsuan Chou）
Position：
領域應用科學家 (Field Application Scientist)
Affiliation：
圖爾思生物科技股份有限公司 (BIOTOOLS CO., LTD.)
Email：
Photo：
Research Interests：
Physiology, pharmacology, molecular biology and microbiology
Selected Publications：
1. Lee PH, Wu CJ, Hung YW, Lee CJ, Chi CT, Lee IH, Kuo YL, Chou SH, Luo JC, Hou MC, Huang YH, Gut microbiota and metabolites associate with outcomes of immune checkpoint inhibitor–treated unresectable hepatocellular carcinoma. Journal for ImmunoTherapy of Cancer 2022;10:e004779. (Impact factor: 11.367)
2. Kolesar, Jill; Wang, Catherine; Allen, Robyn; Taguchi, Yumiko; SH Chou; Kaufman, Brett, Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome. Nucleic Acids Research, 2012, 1–14. (Rank: 27/290 Biochemistry & Molecular Biology, Impact factor: 8.278)
3. SH Chou, YC Lee, YR Wang, CF Huang, HP Yu and YT Lau. Gender-specific effects of caloric restriction on the balance of vascular nitric oxide and superoxide radical. Cardiovascular Research. 2010, 87 (4): 751-759. (Rank: 6/79 in cardiac & cardiovascular systems, Impact factor: 5.947)
Abstract：
The mainstream method to identify and analyze bacterial is the 16S rRNA gene sequencing. The nearly 1500 bp 16S rRNA gene includes nine variable regions as known the highly conserved 16S sequence. BIOTOOLS CO., LTD. provides better taxonomic resolution using full-length 16S gene sequencing compared conventional V3-V4 sequencing. Nevertheless, our bioinformatic pipeline demonstrates taxonomic resolution at species and strain level. BIOTOOLS CO., LTD. also provides untargeted metabolomics for annotating metabolites that correlate with microbes and further accentuates the potential role of gut microbiota and metabolites as biomarkers to predict outcomes of several disease models.