講師資料
Talks：
The sleep physiological change with artificial light intervention in female young adolescents - a magnetic resonance spectroscopy(MRS) study
介入性人工光照對於女性青少年的睡眠生理改變- 核磁共振光譜儀研究
Name：
呂宗樺（Tsung-Hua, Lu）
Position：
Attending physician
Affiliation：
Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital
Email：
Photo：
Research Interests：
Psychiatry, Psychotherapy, Sleep medicine, Artificial Intelligence in Mental Health
Selected Publications：
(1) Lu T-H, Chen PS, Chen KC, Lee IH, Yang YK: Poor Sleep in Medicated Patients with Remitted Depressive Disorder: A Naturalistic Study. Taiwanese Journal of Psychiatry (Taipei) 2020 Mar; 34(1):42-46
(2) Lu T-H, Lin S-H, Chi MH, Chu C-L, Yang D-Y, Chang WH, Chen PS, Yang YK*: Harm avoidance is correlated with the reward system in adult patients with attention deficit hyperactivity disorder—a fMRI study. Clinical Psychopharmacology and Neuroscience (2021 Nov in press) (SCI) (I.F: 3.731)
(3) Lu T-H, Hsieh YT, Lin SH, Yang YK, Chen PS*: Childhood Trauma is Related to Sleep-related Daytime Dysfunction, and Is Buffered with Social Support among Patients with Bipolar II Disorder. Taiwanese Journal of Psychiatry (Taipei) 2022 Mar 29;36:25-31.
(4) Lu TH, Lin SH, Tseng HH, Yang YK, Chiu NT, Chen PS. Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1. Clin Psychopharmacol Neurosci. 2022 Nov 30;20(4):768-772. (SCI) (I.F: 3.731)
(5) Chih-En Kuo, Tsung-Hua Lu, Guan-Ting Chen, Po-Yu Liao, Towards precision sleep medicine: Self-attention GAN as an innovative data augmentation technique for developing personalized automatic sleep scoring classification, Computers in Biology and Medicine, Volume 148, 2022, 105828 (SCI) (I.F: 6.698)
(6) Yen-Chin Chen, Tsung-Hua Lu, En-Ni Ku, Chia-Te Chen, Ching-Ju Fang, Pei-Chun Lai, Chieh-Hsiu Liu, Efficacy of brief behavioural therapy for insomnia in older adults with chronic insomnia: a systematic review and meta-analysis from randomised trials, Age and Ageing, Volume 52, Issue 1, January 2023 (SCI) (I.F: 12.782)
(7) Lu TH, Lin SH, Chen PS, Huang SM, Yang YK. Mindfulness-based stress reduction training was associated with the level of depression and attention among patients with Graves' disease. Gen Hosp Psychiatry. 2023 Jul-Aug;83:205-206. (SCI) (I.F: 7.857)
(8) 國衛院論壇- 臺灣鎮靜安眠藥不當使用之防治策略：臺灣鎮靜安眠藥不當使用之防治策略建言書（ISBN: 978-986-5469-21-4）。出版年月: 民國110年5月(共同撰寫者)
Abstract：
青少年的睡眠品質影響情緒、人際關係及學業表現，亦是台灣需要被重視的議題。對於尚未有嚴重睡眠困擾的青少年，我們有許多可以介入改善睡眠品質的方式，其中一項便是人工光照。人工光照藉由改變褪黑激素分泌的時間點，進而影響睡眠的品質，也進而影響大腦功能而改變情緒。然而，人工光照介入多為實驗室場域的研究，在真實世界中以學校教室為人工光照介入場域的研究非常少，以及人工光照對於大腦γ-胺基丁酸(GABA)及麩胺酸(glutamate)，各為中樞神經抑制及刺激的神經傳導物質之改變，亦是值得探討的研究方向。此研究乃針對南部一所女子高中，在學校教室安裝高照度及高色溫的人工光照設備，於學生上午上課期間給於光照約兩個月，比較實驗組與控制組，在以多頻道睡眠生理檢查儀(polysomnography, PSG)檢測的睡眠品質、昏暗光線褪黑激素分泌時間點(dim light melatonin onset, DLMO)、核磁共振光譜儀(magnetic resonance spectroscopy, MRS)測量的腦活性，以及與睡眠情緒相關的量表，來作為前後測對照指標。研究發現白天主觀焦慮情緒強度與睡眠相角值(phase angle)呈顯著負相關(r= -0.72, p=0.05)，而人工光照介入後，造成睡眠相角值減少、第三期睡眠減少、大腦GABA抑制功能增加、Glutamate/GABA減少，這些結果顯示真實世界中的人工光照可能影響青少年褪黑激素的分泌及大腦調控抑制的功能增加。
2023年會：
10/28 13:40 14:40-15:00
介入性人工光照對於女性青少年的睡眠生理改變- 核磁共振光譜儀研究 [會議室2]
10/29 12:30 【費雪派克】
How to improve the CPAP compliance of OSA patients [會議室1]