(1) Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Tung-Yen Lee, Fang-Chia Chang*. A prolonged stress rat model recapitulates some PTSD-like changes in sleep and neuronal connectivity. Communications Biology 2023; 6:716; https://doi.org/10.1038/s42003-023-05090-9.
(2) Tung-Yen Lee, Pei-Lu Yi, Fang-Chia Chang*. Hypocretin role in posttraumatic stress disorder-like behaviors induced by a novel stress protocol in mice. Frontiers in Psychiatry 2023; 14:1196994; https://doi.org/10.3389/fpsyt.2023.1196994.
(3) Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Fang-Chia Chang*. Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration. Sleep 2022; 45(3): zsab301; https://doi.org/10.1093/sleep/zsab301.
(4) Yun Lo, Yi-Tse Hsiao, Fang-Chia Chang*. Use electroencephalogram entropy as an indicator to detect stress-induced sleep alteration. Applied Sciences 2022; 12(10): 4812; https://doi.org/10.3390/app12104812.
(5) I-Chen Li, Fang-Chia Chang#, Ching-Chuan Kuo, Hsin-Tung Chu, Tsung-Ju Li, Chin-Chu Chen. Pilot study: Nutritional and preclinical safety investigation of fermented hispidin-enriched Sanghuangporus sanhuang mycelia: a promising functional food material to improve sleep. Frontiers in Nutrition 2022; 8: 788965; https://doi.org/10.3389/fnut.2021.788965.
(6) Tsung-Ju Li, Tung-Yen Lee, Yun Lo, Li-Ya Lee, I-Chen Li, Chin-Chu Chen, Fang-Chia Chang*. Hericium erinaceus mycelium ameliorate anxiety induced continuous sleep disturbance in vivo. BMC Complementary Medicine and Therapy 2021; 21: 295.
(7) I-Chen Li, Ting-Wei Lin, Tung-Yen Lee, Yun Lo, Yih-Min Jiang, Yu-Hsuan Kuo, Chin-Chu Chen, Fang-Chia Chang*. Oral delivered Armillaria mellea promotes non-rapid eye movement and rapid eye movement sleep in rats. Journal of Fungi 2021; 7(5): 371.
(8) Yi-Tse Hsiao, Ta-Ching Chen, Pin-Huan Yu, Ding-Siang Huang, Fung-Rong Hu, Cheng-Ming Chuong, Fang-Chia Chang*. Connectivity between nidopallium caudolateral and visual pathways in color perception of zebra finches. Scientific Reports 2020; 10: 19382; DOI: https://doi.org/10.1038/s41598-020-76542-z.
(9) Shuo-Bin Jou, Chung-Jen Tsai, Chun-Ying Fang, Pei-Lu Yi, Fang-Chia Chang*. Effects of N6-(4-hydroxybenzyl) adenine riboside in stress-induced insomnia in rodents. Journal of Sleep Research 2020; DOI: 10.1111/jsr13156.
(10) Hsin-Tzu Tseng, Yi-Tze Hsiao, Pei-Lu Yi, Fang-Chia Chang*. Deep brain stimulation (DBS) increases epilepsy threshold by altering REM sleep and delta powers during NREM sleep. Frontiers in Neurology 2020; DOI: 10.3389/fneur.2020.00752.
(11) Yi-Tse Hsiao, Yun Lo, Pei-Lu Yi, Fang-Chia Chang*. Hypocretin in median raphe nucleus modulates footshock stimuli-induced REM sleep alteration. Scientific Reports 2019; 9: 8198.
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| This presentation showcases the effectiveness of an inhibitor targeting equilibrative nucleoside transporter (ENT)-1 for addressing both Alzheimer's disease (AD) and the associated sleep disturbances. Our findings demonstrate that the ENT1 inhibitor effectively countered the elevation of nitric oxide, caspase 3, and phosphorylated γ-H2AX. It also heightened the activity of nuclear DNA-dependent serine/threonine protein kinase (DNA-PKcs) through the non-homologous end joining (NHEJ) pathway, aiding in the mending of DNA double-strand breaks. This intervention mitigated the loss of cholinergic neurons in AD-afflicted mice. Notably, the ENT1 inhibitor ameliorated cognitive deficits observed in tasks like the Morris Water Maze (MWM) and Novel Object Recognition (NOR). Moreover, our investigation revealed that the ENT1 inhibitor not only relieved sleep disruptions induced by AD but also displayed efficacy in managing stress-induced insomnia. Given the intertwined nature of sleep disruption and AD progression, our results underscore the potential of this innovative ENT1 inhibitor as a prospective treatment for Alzheimer's disease. |