(1) Yun Lo, Yi-Tse Hsiao*, Fang-Chia Chang* (2022, May) Use electroencephalogram entropy as an indicator to detect stress-induced sleep alteration. Applied Sciences 12.10: 4812.
(2) Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Fang-Chia Chang (2021, Dec) Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration. SLEEP
(3) Yi-Tse Hsiao, Ta-Ching Chen, Pin-Huan Yu, Ding-Siang Huang, Fung-Rong, Hu, Cheng-Ming Chuong, Fang-Chia Chang (2020, Nov) . Connectivity between nidopallium caudolateral and visual pathways in color perception of zebra finches. Scientific Reports, 19382 https://www.nature.com/articles/s41598-020-76542-z
(4) Wan-Ting Liao, Chao-Lin Chang, Yi-Tse Hsiao (2020, Jun) Activation of cannabinoid type 1 receptors decreases the synchronization of local field potential oscillations in the hippocampus and entorhinal cortex and prolongs the interresponse time during a differential‐reinforcement‐of‐low‐rate task. European Journal of Neuroscience https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14856
(5) Yi-Tse Hsiao, Yun Lo, Pei-Lu Yi, Fang-Chia Chang (2019, Jun). Hypocretin in median raphe nucleus modulates footshock stimuli-induced REM sleep alteration. Scientific Reports, 9:8198. https://www.nature.com/articles/s41598-019-44731-0
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| A single stressful experience often disrupts subsequent sleep, but the precise mechanisms underlying this phenomenon remain unclear. We hypothesized that emotional memories consolidated within ventral hippocampal neurons projecting to the lateral hypothalamus contribute to stress-induced sleep disturbances. Employing activity-dependent neural tagging in mice, we labeled footshock-activated neurons in the lateral hypothalamus. Reactivation of these neurons significantly reduced sleep duration by more than 6 hours. Remarkably, inhibition of ventral hippocampal during footshock exposure ameliorated sleep disruptions. We further demonstrated that stressful experiences activate ventral hippocampal neurons, subsequently stimulating orexinergic neurons in the lateral hypothalamus, leading to sleep disturbances. Our findings suggest that fear-induced reactivation of orexinergic neurons, receiving input from the ventral hippocampus, plays a crucial role in sleep disruption following stressful events. |