講師資料
Talks：
Obstrutive Sleep Apnea and the Risk of Cognitive Decline in Older Adults: What is the evidence?
Name：
Professor Brendon Yee
Position：
Professor
Affiliation：
Head, Discipline of Sleep Medicine, Sydney Medical School, and Sydney University. Clinical Professor, Central Clinical School, University of Sydney
Email：
Photo：
Research Interests：
I am currently a Senior Staff Specialist, Department of Respiratory and Sleep Medicine. I am the clinical director of the Sleep and Respiratory Failure Unit. This is a busy quaternary referral centre for complex sleep and respiratory failure patients. We provide a world recognised sleep, acute and chronic respiratory failure service. We have at least 300 patients on long term non-invasive ventilation and perform over 1000 sleep studies per year.
I am also a senior research fellow at the Woolcock Institute of Medical Research (WIMR) in the Sleep and Circadian Group. I am a senior clinician in the multi-disciplinary Woolcock Clinic. I also provide clinical service for rural NSW in Dubbo (MSOP Programme) since 2001.
Selected Publications：
I have authored over 130 career publications including 65 original research papers
• All original research papers are clinical research including many randomised controlled trials
• My work has been cited over 5000 times (H-index =31), with 2600 citations
• 5 of my papers have attracted editorials in top sleep/respiratory journals
Journals
(1) Stranks L, Ellender C, Wong K, Naqvi H, Grunstein R, Yee BJ, Sivam S. Hypersomnia of Central Origin: an epidemiological perspective from two Australian tertiary hypersomnolence clinics. Intern Med J (accepted)
(2) Teh JZ, Grummitt L, Haroutonian C, Cross NE, Skinner B, Bartlett DJ, Yee BJ, Grunstein RR, Naismith SL, D’Rozario AL. Overnight Declarative memory Consolidation and NREM Sleep EEG Oscillations in Older Adults with Obstructive Sleep Apnea. Sleep 2023 (accepted)
(3) Harper C, Seimon R, Yee B, Salis A, Cayanan E. Translating evidence into practice: A Case Study of extended use of very low energy diet for treatment of co-morbid obesity and chronic disease. Recent Progress in Nutrition 2022 (accepted)
(4) Lavender I, McCartney D, Marshall NS, Suraev A, Irwin C, D’Rozario A, Gordon C, , Saini B, Grunstein R, Yee BJ, McGregor IS, Hoyos C. Cannabinol (CBN:30 and 300mg) effects on sleep and next-day function in insomnia disorder (CUPID study): Protocol for a randomised, double-blind, placebo-controlled, crossover, three-arm, proof-of-concept trial. A randomised, double-blind, placebo-controlled, crossover, three-arm, proof-of-concept trial. BMJ Open 2022 (Accepted)
(5) Tuft C, Matar E, Schrire ZM, Grunstein RR, Yee BJ, Hoyos CM. Risk of using melatonin for sleep disorders in older adults: Current insights. Clinical Investigations in Ageing 2023 (Accepted)
(6) Nanayakkara B, Di Michiel J, Yee BJ. Restless leg syndrome. Australian Journal General Practice 2023 (accepted).
Abstract：
There is emerging evidence that obstructive sleep apnea is a risk factor for cognitive impairment and dementia. OSA is characterised by frequent pauses in breathing due to upper airway closure during sleep. These events lead to severe sleep fragmentation and intermittent hypoxia. Nocturnal hypoxia related neuroinflammation and oxidative stress in the brain while sleep fragmentation increases neuronal activity and amyloid-B release. These changes may also lead to the impairment of glial-lymphatic “glymphatic” fluid clearance further leading to accumulation of amyloid-B and tau protein leasing to the formation of plaques or tangles in the brain. Neuroimaging in OSA show neuroanatomical changes that are parallel to those seen in ageing. Whether these changes are accelerated by OSA or other comorbid disorders remains to be tested. Therapy of OSA with CPAP may reverses some of these changes. CPAP may also improve cognition and prevent cognitive decline. Although there is considerable heterogeneity into which cognitive domains improve with CPAP. CPAP may also improve neuroimaging and other potential blood biomarkers of dementia. We will discuss the literature and the gaps in knowledge we have in this important area of research.
2023年會：
10/29 10:00 Obstrutive Sleep Apnea and the Risk of Cognitive Decline in Older Adults: What is the evidence? [會議室1-會議室2-會議室3]