講師資料
Talks：
Metabolic Regulation of the Circadian Clock in the Suprachiasmatic Nucleus
視叉上核中樞時鐘的代謝調節
Name：
黃榮棋（Rong-Chi Huang）
Position：
Associate Professor
Affiliation：
Department of Physiology and Pharmacology
College of Medicine, Chang Gung University
Email：
Photo：
Research Interests：
Ion channels, Ion imaging, Circadian rhythms
Selected Publications：
(1) Cheng PC, Cheng RC, Huang RC (2023) Glutamate-evoked Ca2+ responses in the rat suprachiasmatic nucleus: Involvement of Na+/K+-ATPase and Na+/Ca2+-exchanger. Int J Mol Sci 24:6444. https://doi.org/10.3390/ijms24076444
(2) Yang JJ, Huang RC (2022) Afterhyperpolarization potential modulated by local [K+]o in K+ diffusion-restricted extracellular space in the central clock of suprachiasmatic nucleus. Biomed J https://doi.org/10.1016/j.bj.2022.07.005
(3) Yang JJ, Cheng RC, Cheng PC, Wang YC, Huang RC (2017) KATP channels mediate differential metabolic responses to glucose shortage of the dorsomedial and ventrolateral oscillators in the central clock. Sci Rep 7:640. DOI:10.1038/s41598-017-00699-3.
Abstract：
The suprachiasmatic nucleus (SCN) is the central clock controlling mammalian circadian rhythms of physiology and metabolism. The SCN is metabolically active and responds to glucose shortage to regulate photic entrainment. To determine how energy metabolism regulates the SCN, we showed that the mitochondria-associated glycolytic pathway is sensitive to glucose shortage in the rat SCN and demonstrated a glucose-sensing property of KATP channels to regulate excitability in the AVP/Kir6.2-containing SCN neurons. Our recent results further suggested that the mitochondria-fueled Na+/K+-ATPase (NKA) may also act as a glucosensor to regulate [Ca2+]i in the SCN. The glucose-sensing ability of the mitochondria-associated glycolytic pathway, KATP, and NKA may endow the SCN with multiple mechanisms to react to glucose shortage. In particular, NKA also potently regulates glutamate-evoked Ca2+ signaling and may thus play a role in the (patho)physiology of light/glutamate-induced phase shift.
2023年會：
10/29 11:00 12:00-12:30
Metabolic Regulation of the Circadian Clock in the Suprachiasmatic Nucleus [會議室4]