1.Department of Infectious and immunity pulmonary disease, Chang Gung Memorial Hospital, Linkou, Taiwan
2.Department of Thoracic Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan
3.Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan
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(1) Chuang LP, Pang JS, Lin SW, Hung KC, Hu HC, Kao KC, Wen MS, Chen NH*. (2022, Jan). Elevated serum matrix metalloproteinase-2 levels in heart failure patients with reduced ejection fraction and Cheyne-Stokes respiration. J Clin Sleep Med, 2022 May 1;18(5):1365-1373. doi: 10.5664/jcsm.9870.
(2) Chuang LP, Wu HP, Lee LA, Chiu LC, Lin SW, Hu HC, Kao KC, Chen NH, Tsai JW, Pang JH* (2021, Oct). Elevated Monocytic Interleukin-8 Expression under Intermittent Hypoxia Condition and in Obstructive Sleep Apnea Patients. International Journal of Molecular Sciences, 2021, 22(21), 11396;
https://doi.org/10.3390/ijms222111396.
(3) Chen YL, Chuang LP*, Lin SW, Huang HY, Liu GH, Hsu HF, Chen NH. (2021 Aug) Effects of Pressure Control Device (SensAwake) on Obstructive Sleep Apnea (OSA) Patients Who Remove the Mask for Unknown Reasons during Automatic Continuous Positive Airway Pressure (Auto-CPAP) Therapy: A Prospective Randomized Crossover Trial. Medicina (Kaunas). 2021 Aug 31;57(9):915.
(4) Chuang LP; Hsieh MJ; Chen NH; Hu HC; Yang CT; Tsai YH; Lin SW*. (2021, Jul). Total Sleep Time in the Taiwan Obstructive Lung Disease Cohort. Int J Environ Res Public Health, 2;18(13).
(5) Chuang LP, Lin SW, Lee LA, Chang CH, Huang HY, Hu HC, Kao KC, Hsieh MJ, Yang CT, Li HY, Chen NH*. (2019, Feb). Elevated Serum Markers of Acute Kidney Injury in Patients with Obstructive Sleep Apnea. Journal of Clinical Sleep Medicine, 15(2):207-213. (SCI). MOST 106-2314-B-182A-073.
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Obstructive sleep apnea (OSA), defined as repeated episodes of obstructive apnea and hypopnea during sleep, together with symptoms of daytime sleepiness or frequently altered cardiopulmonary function, affects at least 5% of the general population. OSA results in intermittent hypoxia (IH) and sleep fragmentation with neurocognitive dysfunction and cardiovascular disease as the major sequelae.
There are several treatment methods, including ventilator, oral appliance and surgery, etc., each one has different advantages and disadvantages. However, according to the American Academy of Sleep Medicine's treatment guidelines for obstructive sleep apnea, the current first-choice treatment is the use of positive airway pressure ventilator.
This speech mainly focuses on the clinical practice on of sleep ventilators, which includes continue positive airway pressure ventilator (CPAP), automatic positive airway pressure ventilator (APAP) and even bi-level positive airway pressure ventilator (BiPAP). We pay more attention to the issue of how to improve the compliance of PAP treatment in OSA patients. I wish that in this 40-minutes talk, the listeners can get relevant concepts and gains in this field.
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