| Talks： |
Sleep Apnoea and Sleep Syncope in Dogs
犬隻睡眠呼吸中止症及睡眠暈厥症 |
| Name： |
| 劉乃潔（Nai-Chieh Liu） |
| Position： |
| 小動物外科助理教授 |
| Affiliation： |
國立台灣大學獸醫專業學院
臨床動物醫學研究所
小動物耳鼻喉暨臨床睡眠研究室
|
| Email： |
|
| Photo： |
 |
| Research Interests： |
| 短吻犬阻塞性呼吸道症候群、犬隻睡眠呼吸中止症及暈厥症、犬貓鼻咽狹窄及後鼻孔閉鎖、犬貓頭頸癌、氣道外科 |
| Selected Publications： |
1. Franklin PH, Riggs J, Liu N-C*. Comparison of the effectiveness of three different rhinoplasty techniques to correct stenotic nostrils using silicon models: A case study. Veterainry Surgery. 2024 Jan;53(1):104-112. doi:10.1111/vsu.14041.Epub 2023 Oct 9. PMID:37814310
2. Liu N-C, Genain MA, Kalmar L, Sargan DR, Ladlow JF. Objective effectiveness of and indications for laser-assisted turbinectomy in brachycephalic obstructive airway syndrome. Veterinary Surgery. 2019;48(1):79-87.
3. Hinchliffe TA, Liu N-C, Ladlow JF. Sleep-disordered breathing in the Cavalier King Charles Spaniel: a case series. Veterinary Surgery. 2019;48(4):497-504.
4. Liu N-C, Oechtering GU, Adams VJ, Kalmar L, Sargan DR, Ladlow JF. Outcomes and prognostic factors of surgical treatments for brachycephalic obstructive airway syndrome in 3 breeds. Veterinary Surgery. 2017;46(2):271-280.
5. Liu N-C, Adams VJ, Kalmar L, Ladlow JF, Sargan DR. Whole body barometric plethysmography characterizes upper airway obstructions in 3 brachycephalic breeds of dogs. Jounral of Veterinary Internal Medicine. 2016;30(3):853-865. |
| Abstract： |
| In dogs, various conditions can disrupt sleep, with narcolepsy, REM sleep behaviour disorders, and sleep-disordered breathing (SDB) being the most prevalent causes. Research has shown that sleep apnoea is present in 65% of dogs affected by brachycephalic obstructive airway syndrome. During REM sleep, bulldogs exhibit episodes of both central and obstructive apnoea, significantly associated with the suppression of the drive to both the diaphragm and pharyngeal dilating muscle contractions. Current treatments for canine sleep apnoea include upper airway corrective surgery and serotonin/serotoninergic drugs. However, the fundamental mechanisms of SDB during REM sleep have been understudied due to the limited access to polysomnography in veterinary clinical settings.
The bulldog was originally suggested as a naturally occurring animal model for human sleep apnoea. However, discrepancies in sleep cycles, behaviours and upper airway anatomy imply that the mechanisms of sleep apnoea in humans and dogs may not be directly comparable. Dogs are obligate nasal breathers when asleep, and obstruction in any part of the nasal airway (i.e. from the external nostrils to the end of the nasopharynx) can lead to SDB in dogs. Both brachycephalic breeds and miniature canine breeds are prone to SDB, including breathing-related sleep syncope. Affected dogs can develop serious systemic consequences such as cardiovascular disorders. In our study, we aim to investigate canine sleep apnoea from a One Medicine perspective, focusing on exploring the mutual characteristics of SDB between humans and dogs.
|
| 2024年會： |
10/12 13:40 Sleep apnea and sleep syncope in dogs
犬隻睡眠呼吸中止症及睡眠暈厥症 [會議室3]
|