講師資料
Talks：
Rehabilitation for Sleep Apnea and Stroke Prognosis
睡眠呼吸中止症復健對中風預後的影響
Name：
黃相碩（Shiang-Suo Huang）
Position：
Professor
Affiliation：
Affiliation Department of Pharmacology and Institute of Medicine, Chung Shan Medical University
Department of Pharmacy, Chung Shan Medical University Hospital
Email：
Photo：
Research Interests：
Pharmacological effect of traditional medicine
Drug Development for myocardial infarction and ischemic stroke
Mechanism of myocardial ischemia/reperfusion and focal cerebral ischemia/reperfusion injury
Selected Publications：
1. Tsai CF, Lin HW, Liao JM, Chen KM, Tsai JW, Chang CS, Chou CY, Su HH, Liu PH, Chu YC, Wang YH, Wang M, Huang SS* (2023, Feb). Dunaliella salina Alga Protects against Myocardial Ischemia/Reperfusion Injury by Attenuating TLR4 Signaling. Int J Mol Sci, 24(4):3871.
2. Lin CW, Li JY, Kuo TBJ, Huang CW, Huang SS*, Yang CCH*. (2023, Jan). Chronic intermittent hypoxia worsens brain damage and sensorimotor behavioral abnormalities after ischemic stroke: Effect on autonomic nervous activity and sleep patterns. Brain Res, 1798:148159.
3. Wang YH, Liao JM, Chen KM, Su HH, Liu PH, Chen YH, Tsuei YS, Tsai CF, Huang SS*. (2022, Dec). Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke. Neuropharmacology, 221:109277.
4. Huang SS, Su HH, Chien SY, Chung HY, Luo ST, Chu YT, Wang YH, MacDonald IJ, Lee HH, Chen YH. (2022, Jul). Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol. J Neuroinflammation, 19(1):192.
5. Su HH, Yen JC, Liao JM, Wang YH, Liu PH, MacDonald IJ, Tsai CF, Chen YH, Huang SS* (2021, Dec). In situ slow-release recombinant growth differentiation factor 11 exhibits therapeutic efficacy in ischemic stroke. Biomed Pharmacother. , 144:112290.
6. Tsai MJ, Liou DY, Chu YC, Chen Y, Huang MC, Huang WC, Cheng H, Tsai SK, Huang SS*. (2021, Mar). Minocycline exhibits synergism with conditioned medium of bone marrow mesenchymal stem cells against ischemic stroke. J Tissue Eng Regen Med., 15(3):279-292.
7. Chen WC, Chang LH, Huang SS, Huang YJ, Chih CL, Kuo HC, Lee YH, Lee IH. (2019, Oct). Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain. J Neuroinflammation, 16(1):187.
8. Su HH, Liao JM, Wang YH, Chen KM, Lin CW, Lee IH, Li YJ, Huang JY, Tsai SK, Yen JC, Huang SS* (2019, Mar). Exogenous GDF11 attenuates non- canonical TGF-β signaling to protect the heart from acute myocardial ischemia-reperfusion injury. Basic Res Cardiol., 114(3):20.
Abstract：
Sleep apnea (SA) is prevalent among stroke patients. It contributes to stroke onset and poor prognosis due to intermittent hypoxia (IH)-induced sympathetic hyperactivity, elevated blood pressure, disrupted baroreflex sensitivity, and fragmented sleep. We employed an animal model to replicate the pathological process observed in patients with SA following a stroke and revealed the relationship between changes in physiological parameters and poststroke prognosis. SA treatment following stroke not only significantly alleviated elevated blood pressure standard deviation (BPSD) levels, poor sleep quality, unstable sleep patterns, and sleep disruptions but also ameliorated sensorimotor and cognitive function while mitigating brain damage. Through stepwise analysis, BPSD and sleep patterns were identified as key factors, potentially serving as markers for assessing the effectiveness of continuous positive airway pressure (CPAP) therapy and predicting poststroke prognosis in patients with SA. These findings enhance understanding of the poststroke evolution of physiological parameters with SA treatment and their effect on prognosis. We highlighted the importance of long-term adherence to CPAP therapy for maintaining autonomic activity and promoting better sleep, thereby contributing to improved stroke management in patients with SA.
2024年會：
10/12 14:10 Rehabilitation for Sleep Apnea and Stroke Prognosis
睡眠呼吸中止症復健對中風預後的影響 [會議室3]