講師資料
Talks：
New therapeutic approaches for insomnia
失眠的新型治療方式
Name：
張芳嘉（Fang-Chia Chang）
Position：
Distinguished Professor 特聘教授
Affiliation：
國立臺灣大學獸醫學系
國立臺灣大學神經生物與認知科學研究中心主任
國立臺灣大學生命科學院跨領域神經科學國際研究生博士學位學程主任
Email：
Photo：
Research Interests：
Neuroimmunomodulation in sleep-wake regulation, neurological diseases (Parkinson’s disease, Alzheimer’s disease, epilepsy, stress, and posttraumatic stress disorder (PTSD))-related sleep disruptions and their neural circuits, novel therapeutic approaches for epilepsy, PTSD, Alzheimer’s disease and insomnia, herbal drug development and acupuncture therapy.
Selected Publications：
1. Yu-Jie Su, Pei-Lu Yi, Fang-Chia Chang*. Transcranial direct current stimulation (tDCS) ameliorates stress-induced sleep disruption via activating infralimbic cortex-ventrolateral preoptic area projections. Brain Sciences 2024; 14(1):105 DOI:10.3390/brainsci14010105
2. Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Tung-Yen Lee, Fang-Chia Chang*. A prolonged stress rat model recapitulates some PTSD-like changes in sleep and neuronal connectivity. Communications Biology 2023; 6:716; https://doi.org/10.1038/s42003-023-05090-9
3. Tung-Yen Lee, Pei-Lu Yi, Fang-Chia Chang*. Hypocretin role in posttraumatic stress disorder-like behaviors induced by a novel stress protocol in mice. Frontiers in Psychiatry 2023; 14:1196994; https://doi.org/10.3389/fpsyt.2023.1196994
4. Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Fang-Chia Chang*. Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration. Sleep 2022; 45(3): zsab301; https://doi.org/10.1093/sleep/zsab301
5. I-Chen Li, Ting-Wei Lin, Tung-Yen Lee, Yun Lo, Yih-Min Jiang, Yu-Hsuan Kuo, Chin-Chu Chen, Fang-Chia Chang*. Oral delivered Armillaria mellea promotes non-rapid eye movement and rapid eye movement sleep in rats. Journal of Fungi 2021; 7(5): 371
Abstract：
Insomnia, a prevalent sleep disorder, has been traditionally managed with hypnotics, which, despite their relative safety, carry the risk of adverse effects. Recent research explores alternative therapeutic approaches, including the modulation of adenosine pathways and non-invasive brain stimulation techniques, to enhance sleep quality and manage insomnia more effectively.
One promising avenue involves the use of a novel equilibrative nucleoside transporter 1 (ENT1) inhibitor, which has demonstrated efficacy in regulating adenosine homeostasis and enhancing non-rapid eye movement (NREM) sleep in preclinical models. This inhibitor was shown to ameliorate both caffeine-induced and stress-induced insomnia in mice. Mechanistic studies revealed that its somnogenic effects are mediated through the activation of adenosine A1 and A2A receptors and the subsequent activation of GABAergic neurons within the ventrolateral preoptic area (VLPO), a key sleep-regulating region in the brain. The ENT1 inhibitor's ability to enhance NREM sleep without affecting REM sleep underscores its potential as a novel therapeutic agent for insomnia treatment.
Another innovative approach involves transcranial direct current stimulation (tDCS), a non-invasive method known for modulating neuronal activity in psychiatric disorders. Targeting the prefrontal cortex, anodal tDCS has been shown to activate glutamatergic projections from the infralimbic cortex (IL) to the VLPO, leading to significant NREM sleep enhancement. In stress-induced insomnia models, tDCS not only increased the number of NREM sleep bouts but also extended the duration of both NREM and REM sleep during acute insomnia episodes. The IL-VLPO pathway was identified as a critical mediator of tDCS's sleep-promoting effects, providing a mechanistic understanding that could guide future clinical applications.
Together, these findings highlight the potential of ENT1 inhibition and tDCS as innovative therapeutic strategies for insomnia, offering new avenues for research and clinical intervention aimed at improving sleep quality and patient outcomes.
2024年會：
10/12 14:40 New therapeutical approaches for insomnia
失眠的新型治療方式 [會議室3]