| Talks： |
| Onset Bifurcation of Circadian Clocks in the Mouse Embryo |
| Name： |
| 明智煥教授（Jihwan Myung） |
| Position： |
| Associate Professor |
| Affiliation： |
| Graduate Institute of Mind, Brain and Consciousness (GIMBC), Taipei Medical University |
| Email： |
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| Photo： |
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| Research Interests： |
Circadian biology (molecular biology and behavior),
Computational neuroscience (nonlinear dynamics, entrainment theory)
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| Selected Publications： |
1. Myung J, Schmal C, Hong S, Tsukizawa Y, et al. (2018). The choroid plexus is an important circadian clock component. Nat. Commun. 9: 1062.
2. Myung J, Pauls SD (2018). Encoding seasonal information in a two-oscillator model of the multi-oscillator circadian clock. Eur. J. Neurosci. 48: 2718-2727.
3. Azzi A, Evans JA, Leise T, Myung J, et al. (2017). Network dynamics mediate circadian clock plasticity. Neuron. 93:441-450.
4. Myung J, Hong S, DeWoskin D, De Schutter E, et al. (2015). GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time. Proc. Natl. Acad. Sci. USA. 112: E3920-E3929.
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| Abstract： |
| Embryonic development presents a unique window into the origins of circadian rhythms, which are crucial biological processes whose disruption can lead to pregnancy complications and neurodevelopmental disorders. Using bioluminescent reporter monitoring, we tracked the emergence and evolution of circadian gene expression oscillations in the mouse embryo throughout development. Contrary to previous findings that identified the suprachiasmatic nucleus (SCN) as the first site of circadian rhythmicity around embryonic day 15.5 (E15.5), we discovered robust PER2 oscillations in the fourth ventricle choroid plexus (4VCP) as early as E12.5. At the threshold of circadian clock emergence, we observed that the oscillatory behavior follows the characteristics of saddle-node on the invariant circle (SNIC) bifurcation, rather than the Hopf bifurcation assumed in the adult circadian clock. Through transcriptional profiling, we demonstrated that this transition coincides with a shift in the expression patterns of other clock genes, supporting the notion of a discrete change in the ‘clock era’ during early development. Our findings challenge the current understanding of circadian rhythm development and highlight the 4VCP as a surprisingly early site of autonomous circadian clock function in the mouse embryo. |
| 2024年會： |
10/13 12:00 Onset Bifurcation of Circadian Clocks in the Mouse Embryo [會議室4]
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