講師資料
Talks：
Effects of the Human-Centric Lighting Intervention on Glutamate/GABA Levels and Salivary Melatonin: A 60-Day Pilot Study in Female Adolescents.
人因光照介入對於女性青少年大腦麩胺酸/γ-胺基丁酸功能/及褪黑激素的影響
Name：
呂宗樺（Tsung-Hua, Lu）
Position：
Deputy Director
Affiliation：
Sleep Medicine Center, National Cheng Kung University Hospital
Email：
Photo：
Research Interests：
General psychiatry, Sleep medicine, Wearable devices
Selected Publications：
1. Lu TH, Lin SH, Tseng HH, Yang YK, Chiu NT, Chen PS. Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1. Clin Psychopharmacol Neurosci. 2022 Nov 30;20(4):768-772.
2. Lu TH, Lin SH, Chen PS, Huang SM, Yang YK. Mindfulness-based stress reduction training was associated with the level of depression and attention among patients with Graves' disease. Gen Hosp Psychiatry. 2023 Jul-Aug;83:205-206.
3. 3, Lu, T. H., Hsieh, T. H., Wang, Y. H., Shaw, F. Z., Chen, P. S., & Liang, S. F. Evaluation of alpha neurofeedback training to enhance sleep in remitted depression and anxiety sufferers with persistent insomnia. Psychiatry research, 2025 APR: 346, 116401.
Abstract：
Background:
Light-based interventions may influence the melatonin system; however, their effects on glutamate/GABA balance remain unclear. This pilot quasi-experimental study evaluated three intervention arms: the human-centric lighting (HCL) system, sleep hygiene education (SHE), and a control group.
Methods:
A total of 44 female students from a high school were enrolled. Three classes were assigned to one of the following conditions: HCL, SHE, or control. At baseline and after a two-month intervention period, participants underwent overnight polysomnography (PSG) and proton magnetic resonance spectroscopy (¹H-MRS) to assess glutamate and GABA concentrations in the anterior cingulate cortex.
Results:
Nighttime salivary melatonin concentrations increased in the HCL group. A significant change in the excitatory/inhibitory (E/I) ratio was observed between the HCL and control groups. Glutamate levels decreased in the HCL group, while no changes were observed in the SHE or control groups. GABA levels decreased only in the control group. Additionally, the SHE group exhibited prolonged sleep latency.
Discussion:
The AIoT human-centric lighting system may represent a feasible intervention capable of modulating neurochemical mechanisms related to sleep. Further research is needed to determine its efficacy among individuals with sleep disorders.  
2025年會：