1. Yi-Tse Hsiao, Ching-Yuan Chang, Ting-Yen Lee, Wen-Sung Lai, Fang-Chia Chang (2024, Nov) Effects of sarcosine (N-methylglycine) on NMDA (N-methyl-D-aspartate) receptor hypofunction induced by MK801: In Vivo calcium imaging in the CA1 region of the dorsal hippocampus. Brain Sci. 2024, 14, 1150. https://doi.org/10.3390/brainsci14111150
2. Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Tung-Yen Lee, Fang-Chia Chang (2023, Jul) A prolonged stress rat model recapitulates some PTSD-like changes in sleep and neuronal connectivity. Communications Biology. https://www.nature.com/articles/s42003-023-05090-9
3. Yun Lo, Yi-Tse Hsiao*, Fang-Chia Chang* (2022, May) Use electroencephalogram entropy as an indicator to detect stress-induced sleep alteration. Applied Sciences 12.10: 4812. https://doi.org/10.3390/app12104812
4. Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Fang-Chia Chang (2021, Dec) Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration. SLEEP
5. Yi-Tse Hsiao, Angela Yu-Chi Wang, Ting-Yen Lee, Ching-Yuan Chang (2021, Jun). Using baseplating and a miniscope preanchored with an objective lens for calcium transient research in mice. JOVE, https://dx.doi.org/10.3791/62611
6. Wan-Ting Liao, Chao-Lin Chang, Yi-Tse Hsiao (2020, Jun) Activation of cannabinoid type 1 receptors decreases the synchronization of local field potential oscillations in the hippocampus and entorhinal cortex and prolongs the interresponse time during a differential‐reinforcement‐of‐low‐rate task. European Journal of Neuroscience https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14856
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| A single stressful experience often disrupts subsequent sleep, but the precise mechanisms underlying this phenomenon remain elusive. We hypothesized that a subset of neurons in the lateral hypothalamus (LH), activated during stressful events, contributes to sleep disruption, and that reactivating these neurons is sufficient to induce such disturbances. Using activity-dependent neural tagging in mice, we labeled footshock-activated LH neurons. Reactivation of these neurons reduced total sleep time by more than 9 hours. Further analysis revealed that both corticotropin-releasing factor (CRF)-producing neurons and orexinergic neurons in the LH contribute to sleep loss. Importantly, CRF neurons play a more critical role than orexinergic neurons: reactivation of CRF neurons caused prolonged sleep disruption for over 12 hours, whereas activating orexinergic neurons disrupted sleep for only about 1 hour. These findings suggest that fear-induced reactivation of CRF neurons is a key driver of sleep disruption following stressful events. |