講師資料
Talks：
Endotypes in Patients with Obstructive Sleep Apnea: Clinical Implications and Limitations
阻塞性睡眠呼吸中止症的病理表現型:臨床意涵與限制
Name：
鄭婉汝（Wan-Ju Cheng）
Position：
Associate investigator, psychiatrist
Affiliation：
National Health Research Institutes, National Center for Geriatrics and Welfare Research
China Medical University Hospital, Department of Psychiatry
China Medical University, Department of Public Health
Email：
Photo：
Research Interests：
Sleep medicine, addiction medicine, occupational mental health
Selected Publications：
1. Liang-Wen Hang, Eysteinn Finnsson, Jón S. Ágústsson, Scott A. Sands, Wan-Ju Cheng*. Increased Loop Gain and Upper Airway Collapsibility among Smoking Patients with Obstructive Sleep Apnea. ERJ Open Research. 2025 August 11(4):01283-2024
2. Liang-Wen Hang, Shinn-Jye Liang, Eysteinn Finnsson, Jón S Ágústsson, Scott A Sands, Wan-Ju Cheng*. Endotypic Traits Characterizing Obesity and Sleep-Related Hypoventilation in Patients with Obstructive Sleep Apnea. Annals of the American Thoracic Society. 2025 May;22(5):749-756
3. Hang-Ju Yang, Yu-Han Huang, Wan-Ju Cheng*. Sedative-hypnotics are associated with additional risk of suicide in older adults: a population-based case-control study. Sleep. 2025 May 23:zsaf136.
4. Yung-An Tsou, Liang-Wen Hang, Eysteinn Finnsson, Jón S. Ágústsson, Scott A. Sands, Wan-Ju Cheng*. Upper airway collapsibility during rapid eye movement sleep tracks the response to upper airway surgery for obstructive sleep apnea. Clinical and Experimental Otorhinolaryngology. 2025 February. 18(1)50-56
5. Liang-Wen Hang, Yi-Chen Tsai, Eysteinn Finnsson, Jón S. Ágústsson, Scott A. Sands, Wan-Ju Cheng*. Sex-specific Age-Related Worsening of Pathological Endotypic Traits in Patients with Obstructive Sleep Apnea. Sleep. 2024 August: zsae185
6. Wan-Ju Cheng, Eysteinn Finnsson, Jón S Ágústsson, Scott A Sands, Liang-Wen Hang*. Endotypic traits of supine position and supine-predominant obstructive sleep apnea in Asian patients. European Respiratory Journal. 2024 January.
7. Wan-Ju Cheng, Eysteinn Finnsson, Eydis Arnardottir, Jón S Ágústsson, Scott A Sands, Liang-Wen Hang*. Relationship between Symptom Profiles and Endotypes among Patients with Obstructive Sleep Apnea. Annals of the American Thoracic Society. 2023 September: 20 (9) 1337-1344.
8. Wan-Ju Cheng, Eysteinn Finnsson, Jón S Ágústsson, Scott A Sands, Liang-Wen Hang*. Continuous positive airway pressure and adherence in patients with different endotypes of obstructive sleep apnea. Journal of Sleep Research. 2023 June:e13999
9. Li TM, Pien LC, Cheng WJ*. Direction and magnitude of social jetlag are associated with obesity: results from a sample of hospital employees. Chronobiology International. 2022 July 39(9) 1242-1248
10. Cheng WJ*, Hang LW, Kubo T, Vanttola P, Huang SC. Impact of sleep timing on attention, sleepiness, and sleep quality among real-life night shift workers with shift work disorder: a cross-over clinical trial. Sleep. 2022 Feb 11; zsac 034.
Abstract：
Obstructive sleep apnea (OSA) is a heterogeneous disorder, and understanding its endotypes facilitates both personalized medicine and deeper insight into respiratory physiology. Traditionally, estimating endotypic traits has been labor-intensive (e.g., CPAP drop method) or invasive (e.g., esophageal manometry). More recently, the Phenotyping Using Polysomnography (PUP) method has gained popularity for its ability to derive endotypic traits from standard polysomnography. In recent years, studies have characterized the distribution of these traits in OSA and examined how they vary by age, sex, body mass index, smoking status, symptoms, and polysomnographic features. Certain endotypic traits have also been proposed as predictors of treatment outcomes for CPAP and upper airway surgery. Future research should aim to further validate methods for measuring endotypic traits, assess their generalizability across diverse populations, investigate how these traits change with age and treatment, and explore the joint effects of multiple endotypic metrics. 
2025年會：