| Talks： |
Medications for Obstructive Sleep syndrome
Body weight reduction
睡眠呼吸中止症藥物治療; 減重 |
| Name： |
| 杭良文（Liang-Wen Hang） |
| Position： |
Professor, China Medical University
Chief of Sleep Medicine Center, China Medical University Hospital
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| Affiliation： |
| China Medical University |
| Email： |
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| Photo： |
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| Research Interests： |
| Pathophysiology of obstructive sleep apnea |
| Selected Publications： |
1. Liang-Wen Hang 1 2, Eysteinn Finnsson 3, Jón S Ágústsson 3, Scott A Sands 4, Wan-Ju Cheng 5 67Increased loop gain and upper airway collapsibility among smoking patients with obstructive sleep apnoea 2025 Aug 4;11(4):01283-2024.DOI: 10.1183/23120541.01283-2024. eCollection 2025 Jul.
2. Liang-Wen Hang 1 2, Shinn-Jye Liang 2, Eysteinn Finnsson 3, Jón S Agústsson 3, Scott A Sands 4, Wan-Ju Cheng 5 6 7 Endotypic Traits Characterizing Obesity and Sleep-related Hypoventilation in Patients with Obstructive Sleep Apnea 2025 May;22(5):749-756.DOI: 10.1513/AnnalsATS.202407-752OC.
3. Yung-An Tsou 1 2 3, Liang-Wen Hang 1 4, Eysteinn Finnsson 5, Jón SÁgústsson 5, Scott A Sands 6, Wan-Ju Cheng 7 8 9Upper Airway Collapsibility During Rapid Eye Movement Sleep Is Associated With the Response to Upper Airway Surgery for Obstructive Sleep Apnea 2025 Feb;18(1):50-56.DOI: 10.21053/ceo.2024.00246. Epub 2024 Dec 24.
4. Liang-Wen Hang 1 2, Yi-Chen Tsai 3, Eysteinn Finnsson 4, Jón S Ágústsson 4, Scott A Sands 5, Wan-Ju Cheng Sex-specific age-related worsening of pathological endotypic traits in patients with obstructive sleep apnea Sleep 2025 Jan 13;48(1):zsae185.DOI: 10.1093/sleep/zsae185 3 67
5. Wan-Ju Cheng a,b,c, Eysteinn Finnsson d, Jón S Ágústsson d, Scott A Sands e, Liang-Wen Hang f, ,g Continuous positive airway pressure and adherence in patients with different endotypes of obstructive sleep apnea 33 (1 )：1 ～9 DOI: 10.1111/jsr.13999
6. Wan-Ju Cheng 1 2 3, Eysteinn Finnsson 4, Jón S Ágústsson 4, Scott A Sands 5, Liang-Wen Hang 6 7Endotypic traits of supine position and supine-predominant obstructive sleep apnea in Asian patients 63(2):2301660 DOI：10.1183/13993003.01660-2023
7. Cheng, Wan-Ju*、Eysteinn Finnsson、Eydis Arnardottir、Jon SAgustsson、Scott A Sands、Liang- Wen Hang* (2023, Sep).Relationship between Symptom Profiles and Endotypes among Patients with Obstructive Sleep Apnea: A Latent Class Analysis. Annals of the American Thoracic Society.
8. Hang-Ju Yang、Cheng, Wan-Ju*、Mi-Chun Hsiao、Sheng-Che Huang、Tomohide Kubo、Liang-Wen Hang、Cynthia Wei-Sheng Lee.Rest–activity rhythm associated with depressive symptom severity and attention among patients with major depressive disorder: a 12-month follow-up study.Frontiers in Psychiatry. 2023 Aug 10;14:1214143. doi: 10.3389/fpsyt.2023.1214143. eCollection 2023
9. Cheng, Wan-Ju、Eysteinn Finnsson、Jon S. Agustsson、Scott A Sands、Liang-Wen Hang*.Continuous positive airway pressure and adherence in patients with different endotypes of obstructive sleep apnea.JOURNAL OF SLEEP RESEARCH.2023 Jul 15;e13999. doi: 10.1111/jsr.13999
10. Liang-Wen Hang、Chun-Sen Huang、Wan-Ju Cheng*.Clinical characteristics of Asian patients with sleep apnea with low arousal threshold and sleep structure change with continuous positive airway pressure.Sleep and Breathing. 2021 Sep;25(3):1309-1317. doi: 10.1007/s11325-020-02235-6. Epub 2020 Oct 29.
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| Abstract： |
Obstructive sleep apnea (OSA) is a relatively common sleep disorder characterized by repetitive narrowing or obstruction of the upper airway, including the nasal cavity, pharynx, and larynx, during sleep. OSA can cause a variety of symptoms and/or complications, such as excessive daytime sleepiness, reduced concentration, hypertension, type II diabetes, and stroke. Obesity is an important risk factor for OSA and is characterized by the abnormal accumulation of fat in the body, including the upper airway. Obesity was associated with 1) increased collapsibility; 2) inadequately compensated OSA. upper airway function; and 3) increased loop gain among Asian patients with OSA. Weight loss is the preferred choice for obese patients with OSA and has been proven effective in reducing AHI. Various therapeutic options exist for patients with overweight or obesity, including diet, behavioral modifications, exercise, pharmacological treatments, and surgical procedures. However, their results are relatively unsatisfactory, and pharmacotherapy and bariatric surgery are generally implemented in obese patients with sleep apnea. After pharmacological treatments, there is not only decreased the body weight , and AHI but also decreased the arousal threshold, .loop gain, collapsibility and increased the airway compensation.
Keywords: Obstructive sleep apnea, Obesity, Weight loss, Pharmacotherapy, Endotype
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| 2025年會： |
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