講師資料
Talks：
Additional Medical Treatments for Obstructive Sleep Apnea
阻塞性睡眠呼吸中止症的其他藥物治療
Name：
王才郁（Tsai-Yu Wang）
Position：
助理教授級主治醫師
Affiliation：
林口長庚胸腔內科
長庚大學醫學系
Email：
Photo：
Research Interests：
Sleep Medicine; Sleep Endoscopy; Sleep Physiology
Selected Publications：
1. Vena D, Op de Beeck S, Yang H, Sumner J, Mann D, Wang TY, Aishah A, Azarbarzin A, Messineo L, Calianese N, Alex R, Esmaeili N, Vanderveken OM, White DP, Wellman A, Huyett P, Sands SA. Lateral wall collapse from sleep endoscopy and airflow shape predicts hypoglossal nerve stimulation efficacy in obstructive sleep apnea. Eur Respir J. 2025 Aug 7
2. Lee WH, Chen YH, Wang TY, Chang WJ, Liao TW, Hung WS, Lin SW, Chen NH, Fang JT, Chuang LP. Association between vitamin D level and sleep quality in the elderly population: a prospective cohort study Sleep Breath. 2025 Jun 24;29(4):225.
3. Wang TY, Huyett P, Yang H, Sumner J, Aishah A, Gell L, Azarbarzin A, Messineo L, Labarca G, White D, Sands S, Wellman A, Vena D. Lateral epiglottic collapse in obstructive sleep apnea is associated with laterally directed pharyngeal collapse. J Clin Sleep Med. 2025 Apr 1;21(4):649-654
4. Yang H, Huyett P, Wang TY, Sumner J, Azarbarzin A, Labarca GPT, Messineo L, Gell LK, Aishah A, Hu WH, White DP, Sands SA, Wellman A, Vena D. Mouth Closure and Airflow in Patients With Obstructive Sleep Apnea: A Nonrandomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2024 Nov 1;150(11):1012-
5. Wang TY, Wu CT, Lin YH. The impact of OSA on benign prostatic hyperplasia and metabolic syndrome Nocturia: a central mechanism analysis Sleep Breath. 2024 Dec;28(6):2597-2599.
6. Lin YH, Wang TY, Wu CT. Exploring the Role of Testosterone in the Differential Outcomes of Continuous Positive Airway Pressure and Glucagon-like peptide 1 Treatments in Obstructive Sleep Apnea. Ann Am Thorac Soc. 2024 Sep;21(9):13458.
7. Vena D, Gell L, Messineo L, Mann D, Azarbarzin A, Calianese N, Wang TY, Yang H, Alex R, Labarca G, Hu WH, Sumner J, White DP, Wellman A, Sands SA. Physiological Determinants of Snore Loudness. Ann Am Thorac Soc. 2024 Jan;21(1):114-121.
8. Labarca G, Vena D, Hu WH, Esmaeili N, Gell L, Yang HC, Wang TY, Messineo L, Taranto-Montemurro L, Sofer T, Barr RG, Stone KL, White DP, Wellman A, Sands S, Redline S, Azarbarzin A. Sleep Apnea Physiological Burdens and Cardiovascular Morbidity and Mortality. Am J Respir Crit Care Med. 2023 Oct 1;208(7):802-813
9. Messineo L, Gell L, Calianese N, Sofer T, Vena D, Azarbarzin A, Labarca G, Taranto-Montemurro L, Yang HC, Wang TY, Kim M, Smith H, White D, Sands S, Wellman A. Effect of Pimavanserin on the Respiratory Arousal Threshold from Sleep: A Randomized Trial Ann Am Thorac Soc. 2022 Aug 10
10. Messineo L, Taranto-Montemurro L, Calianese N, Gell LK, Azarbarzin A, Labarca G, Vena D, Yang HC, Wang TY, Wellman A, Sands SA. Atomoxetine and fesoterodine combination improves obstructive sleep apnoea severity in patients with milder upper airway collapsibility. Respirology. 2022 Nov;27(11):975-982. doi: 10.1111/resp.14326.
11. Wang TY, Huang YC, Lin TY, Ni YL, Lo YL. The outcome of CPAP titration for moderate-severe OSA under drug-induced sleep endoscopy: A randomized controlled crossover trial. Front Neuol 2022 Jun 13;13:882465
Abstract：
Obstructive sleep apnea (OSA) is a highly prevalent disease. Continuous positive airway pressure ventilator (CPAP) is the gold standard first-line therapy. However, almost 50% patients can not tolerate CPAP treatment. Alternative treatment such as medication is a wonderful dream for those patients. Recently, the identification of endotypes underlying this disease may orient the pharmacological therapy, which means the personalized therapy of OSA. In this speech, OSA pharmacotherapy based on the four main endotypes: anatomy (Pcrit), upper airway muscle power, arousal threshold and ventilatory overshoot (loop gain) will be addressed. Medications for weight loss that modify upper airway anatomy may play a role in the management of OSA, and promising results have been obtained with drugs that increase upper airway muscle power during sleep and/or reduce ventilatory overshoot (loop gain). Ideally, a medication that can effectively increase the arousal threshold but not worsen upper airway muscle power will make this strategy encouraging. Recent studies have demonstrated that the use of certain sedatives do not make OSA severity worse and can improve patients’ sleep quality.
2025年會：