| Talks： |
Circadian CSF Dynamics in the Brain’s Closed Compartment
大腦封閉腔室中節律性腦脊髓液動態 |
| Name： |
| Jihwan Myung（明智煥） |
| Position： |
| Associate Professor |
| Affiliation： |
| Laboratory of Braintime, Graduate Institute of Mind, Brain and Consciousness (GIMBC), Taipei Medical University |
| Email： |
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| Photo： |
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| Research Interests： |
Circadian biology (molecular biology and behavior),
Computational neuroscience (nonlinear dynamics, entrainment, chemical kinetics)
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| Selected Publications： |
1. itet, H., Truong, V. H., Myung, J. (2025). Choroid Plexus Hosts the Earliest Detectable Circadian Clock in the Brain. bioRxiv, 2025-09.
2. Sládek, M., Houdek, P., Myung, J., Semenovykh, K., Dočkal, T., Sumová, A. (2024). The circadian clock in the choroid plexus drives rhythms in multiple cellular processes under the control of the suprachiasmatic nucleus. Fluids and Barriers of the CNS, 21(1), 46.
3. Myung J, Schmal C, Hong S, Tsukizawa Y, et al. (2018). The choroid plexus is an important circadian clock component. Nature Communications. 9: 1062.Myung J, Hong S, DeWoskin D, De Schutter E, et al. (2015). GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time. Proceedings of National Academy of Sciences USA. 112: E3920-E3929.
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| Abstract： |
The brain is a closed fluid compartment in which total intracranial volume remains constant (Monro-Kellie doctrine), yet its fluid exchange is dynamic. Cerebrospinal fluid (CSF), the principal intracranial fluid, shows daily cycles that likely reflect circadian control by the choroid plexus (CP). The CP harbors a strong molecular clock, but its influence on CSF dynamics remains poorly understood. We show that in nocturnal mice, tight junction proteins occludin and claudins reach peak expression around the transition between day and night, which suggests rhythmic closure of the paracellular pathway, whereas NKCC1, which drives blood-to-CSF ionic gradients, increases at night. Evans Blue delivered via the retro-orbital route permeates into CSF more readily at night, and the tracer appears in the contralateral cervical lymph node with minimal delay, consistent with tight balance that preserves intracranial volume. This circadian gating of barrier permeability adds a circadian dimension to metabolite clearance that complements sleep-driven glymphatic drainage from brain parenchyma. Proper temporal alignment of the two processes may optimize clearance of slowly soluble species such as amyloid-β, whereas misalignment could impair clearance and accelerate neurodegeneration.
Keywords: Circadian rhythms, choroid plexus, cerebrospinal fluid, blood–CSF barrier, metabolite clearance
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| 2025年會： |
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