1. Huang CG, Lin WN, …, *Lee LA. Exploring the Interplay of Gut Microbiota and Systemic Inflammation in Pediatric Obstructive Sleep Apnea Syndrome and Its Impact on Blood Pressure Status: A Cross-Sectional Study. Int J Mol Sci. 2024 Dec 12;25(24):13344.
2. Huang CG, Lin WN, …, *Lee LA. Alterations in Gut Microbiota Composition Are Associated with Changes in Emotional Distress in Children with Obstructive Sleep Apnea. Microorganisms. 2024 Dec 18;12(12):2626.
3. Chao Y, Chuang HH, … *Lee LA. Interplay of Weight Status and Sleep Autonomic Function in Mediating and Moderating the Link Between Disease Severity and Blood Pressure in Paediatric Obstructive Sleep Apnoea. Clin Otolaryngol. 2025 May;50(3):521-527.
4. Chao YP, Chuang HH, …, *Lee LA. Automated sleep apnea detection from snoring and carotid pulse signals using an innovative neck wearable piezoelectric sensor. Measurement. 2025 Jan;242(Part C): 116102.
5. Chao YP, Chuang HH, …, *Lee LA. Distinguishing severe sleep apnea from habitual snoring using a neck-wearable piezoelectric sensor and deep learning: A pilot study. Comput Biol Med. 2025 May;190:110070.
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Introduction:
This study aimed to examine the relationships between physical activity (PA), cardiometabolic profiles, and body composition in adult patients with obstructive sleep apnea (OSA), with and without metabolic syndrome (MetS).
Methods:
Between September 2021 and August 2023, we conducted a prospective case series at a Taiwanese tertiary medical center, enrolling 44 adult OSA patients. Each participant underwent anthropometric measurements, polysomnography, PA evaluation (via the International Physical Activity Questionnaire-Long Form), one-week heart rate variability (HRV) monitoring (using a wearable electrocardiographic patch), fasting blood tests for lipids, glucose, insulin, and insulin resistance (IR), and body composition analysis via dual-energy X-ray absorptiometry.
Results:
Among the 44 participants, 20 (46%) had OSA with MetS, and 24 (54%) had OSA without MetS. Compared to those with OSA alone, patients with MetS had higher BMI, waist circumference, 3% oxygen desaturation index (ODI3), triglycerides, total body fat percentage (TBF%), and fat mass, but lower mean SpO2, weekend R-R interval, sleep weekday R-R interval, and HDL-C (all p < .05). Weekly metabolic equivalent of task-minutes positively correlated with mean SpO2 and HF power during weekend sleep and inversely with insulin levels, IR, triglycerides, TBF%, fat mass, and LF/HF ratio during both sleep and wakefulness (all p < .05). Walking, rather than moderate or vigorous PA, was positively associated with mean SpO2, weekend awake R-R interval, and HDL-C, and inversely with neck circumference, AHI, ODI3, insulin levels, IR, total cholesterol, LDL-C, and android-to-gynoid fat ratio (all p < .05).
Conclusions:
Obesity, hypoxemia, and increased heart rate were significantly associated with MetS in patients with OSA. PA, particularly walking, may improve blood oxygenation, cardiometabolic health, and body composition in this population. Further studies are warranted to confirm these findings and explore potential interventions.
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