講師資料
Talks：
Resetting the Biological Clock: How Lemborexant Helps Restore Circadian Rhythms and Natural Sleep in Insomnia Patients
Name：
孫瑜（Yu Sun）
Position：
1. Director of Department of Neurology of En Chu Kong Hospital 恩主公醫院神經科主任
2. Adjunct Associate Professor of Neurology, 臺大醫學院醫學系神經科兼任副教授
Affiliation：
1. En Chu Kong Hospital, 恩主公醫院
2. Medical College, National Taiwan University 臺大醫學院醫學系
Email：
Photo：
Research Interests：
sleep, dementia, stroke
Selected Publications：
1. Sun Y, Iwagami M, Watanabe T, Sakata N, Sugiyama T, Miyawaki A, Tamiya N. Factors associated with psychological distress in family caregivers: Findings from nationwide data in Japan. Journal:Geriatrics & Gerontology International, Vol 21, pp. 855–864, 2021. DOI: 10.1111/ggi.14250 PMID: 34322980 tsukuba
2. Sun Y, Iwagami M, Komiyama J, Sugiyama T, Inokuchi R, Sakata N, Ito T, Yoshie S, Matsui H, Kume K, Sanuki M, Kato G, Mori Y, Ueshima H, Tamiya N. Association between types of home healthcare and emergency house calls, hospitalization, and end-of-life care in Japan. Journal:Journal of the American Geriatrics Society (JAGS), Accepted in 2023 tsukuba
3. Sun Y, Iwagami M, Sakata N, Ito T, Inokuchi R, Komiyama J, Kuroda N, Tamiya N. Evaluation of enhanced home care support clinics regarding emergency home visits, hospitalization, and end-of-life care: a retrospective cohort study in a city of Japan. Journal:BMC Health Services Research, Accepted in 2023 tsukuba
4. Sun Y. Retrospective cohort study on combining conventional and telemedicine services to reduce emergency medical burden in rural areas. Affiliation: 筑波大學 地域醫療教育學分野 pcmed-tsukuba
Abstract：
Insomnia is not merely a disruption of sleep—it is often a manifestation of misaligned circadian rhythms. Lemborexant, a dual orexin receptor antagonist (DORA), offers a novel approach to treating insomnia by targeting the neurobiological mechanisms that regulate wakefulness and sleep initiation. This presentation explores how Lemborexant modulates orexin signaling to reduce hyperarousal, thereby facilitating the natural onset and maintenance of sleep.
Recent clinical and mechanistic studies demonstrate that Lemborexant not only improves sleep latency and duration but also contributes to the re-synchronization of circadian rhythms, particularly in patients with delayed sleep phase or fragmented sleep patterns. By promoting sleep that aligns more closely with the body's endogenous biological clock, Lemborexant supports restorative sleep and enhances daytime functioning.
失眠不僅僅是入睡困難或中斷，它通常是晝夜節律紊亂的表現。 Lemborexant 是一種雙食慾素受體拮抗劑 (DORA)，它透過調節覺醒和睡眠啟動的神經生物學機制，為治療失眠患者提供了新的治療方法。本演講探討了 Lemborexant 如何調節食慾素訊號傳導以減少過度覺醒，從而促進自然入睡和維持睡眠。
最近的臨床和機制研究表明，Lemborexant 不僅可以改善睡眠潛伏期和持續時間，還可以促進晝夜節律的重新同步，尤其適用於睡眠相位延遲或睡眠模式碎片化的患者。透過促進與人體內源性生理時鐘更緊密一致的睡眠，Lemborexant 可以支持恢復性睡眠並增強日間功能。 
2025年會：