講師資料
Talks:
Prolonged-release Melatonin: Insomnia and Beyond
Name:
鄭婉汝(Wan-Ju Cheng)
Position:
Associate investigator, psychiatrist
Affiliation:
National Health Research Institutes, National Center for Geriatrics and Welfare Research
China Medical University Hospital, Department of Psychiatry
China Medical University, Department of Public Health
Email:
Photo:
Research Interests:
Sleep medicine, addiction medicine, occupational mental health
Selected Publications:
1. Liang-Wen Hang, Eysteinn Finnsson, Jón S. Ágústsson, Scott A. Sands, Wan-Ju Cheng*. Increased Loop Gain and Upper Airway Collapsibility among Smoking Patients with Obstructive Sleep Apnea. ERJ Open Research. 2025 August 11(4):01283-2024
2. Liang-Wen Hang, Shinn-Jye Liang, Eysteinn Finnsson, Jón S Ágústsson, Scott A Sands, Wan-Ju Cheng*. Endotypic Traits Characterizing Obesity and Sleep-Related Hypoventilation in Patients with Obstructive Sleep Apnea. Annals of the American Thoracic Society. 2025 May;22(5):749-756
3. Hang-Ju Yang, Yu-Han Huang, Wan-Ju Cheng*. Sedative-hypnotics are associated with additional risk of suicide in older adults: a population-based case-control study. Sleep. 2025 May 23:zsaf136.
4. Yung-An Tsou, Liang-Wen Hang, Eysteinn Finnsson, Jón S. Ágústsson, Scott A. Sands, Wan-Ju Cheng*. Upper airway collapsibility during rapid eye movement sleep tracks the response to upper airway surgery for obstructive sleep apnea. Clinical and Experimental Otorhinolaryngology. 2025 February. 18(1)50-56
5. Liang-Wen Hang, Yi-Chen Tsai, Eysteinn Finnsson, Jón S. Ágústsson, Scott A. Sands, Wan-Ju Cheng*. Sex-specific Age-Related Worsening of Pathological Endotypic Traits in Patients with Obstructive Sleep Apnea. Sleep. 2024 August: zsae185
6. Wan-Ju Cheng, Eysteinn Finnsson, Jón S Ágústsson, Scott A Sands, Liang-Wen Hang*. Endotypic traits of supine position and supine-predominant obstructive sleep apnea in Asian patients. European Respiratory Journal. 2024 January.
7. Wan-Ju Cheng, Eysteinn Finnsson, Eydis Arnardottir, Jón S Ágústsson, Scott A Sands, Liang-Wen Hang*. Relationship between Symptom Profiles and Endotypes among Patients with Obstructive Sleep Apnea. Annals of the American Thoracic Society. 2023 September: 20 (9) 1337-1344.
8. Wan-Ju Cheng, Eysteinn Finnsson, Jón S Ágústsson, Scott A Sands, Liang-Wen Hang*. Continuous positive airway pressure and adherence in patients with different endotypes of obstructive sleep apnea. Journal of Sleep Research. 2023 June:e13999
9. Li TM, Pien LC, Cheng WJ*. Direction and magnitude of social jetlag are associated with obesity: results from a sample of hospital employees. Chronobiology International. 2022 July 39(9) 1242-1248
10. Cheng WJ*, Hang LW, Kubo T, Vanttola P, Huang SC. Impact of sleep timing on attention, sleepiness, and sleep quality among real-life night shift workers with shift work disorder: a cross-over clinical trial. Sleep. 2022 Feb 11; zsac 034.
Abstract:
隨著年齡增長,體內褪黑激素分泌下降,為睡眠障礙的重要機制之一。長效型褪黑激素(prolonged-release melatonin, PRM)可模擬生理性分泌,維持夜間穩定血中濃度,相較於速效製劑具有明顯優勢。本演講將綜述長效型褪黑激素 在失眠與其他臨床問題之應用。長效型褪黑激素 半衰期約 3.5–4 小時,經 CYP1A2/2C19 代謝。隨機對照試驗證實,每晚 2 mg 長效型褪黑激素可顯著縮短入睡時間、改善睡眠品質,目前尚未發現耐受性、停藥後失眠反彈或戒斷症狀。與傳統安眠藥不同,長效型褪黑激素不影響認知、記憶或姿勢穩定。新興研究亦顯示其對於晝夜節律障礙、快速動眼期睡眠行為障礙、譫妄、偏頭痛、代謝調控,以及注意力不足過動症、自閉症與雙相情感障礙等具潛在助益。透過恢復晝夜節律,長效型褪黑激素 為老年失眠治療的安全選擇,並展現跨領域的臨床應用前景
2025年會: