講師資料
Talks：
Investigating White Matter Microstructure in Narcolepsy Using Diffusion MRI
以擴散磁振造影探討猝睡症之白質神經微結構
Name：
葉俊宏（Chun-Hung Yeh）
Position：
Assistant Professor
Affiliation：
Department of Medical Imaging and Radiological Sciences Chang Gung University
Email：
Photo：
Research Interests：
Diffusion MRI; tractography; connectomics; neuroimaging; computational modelling
Selected Publications：
1. Magioncalda P, Yeh CH*, Lin HY, Tseng RY, Dabiri E, Conio B, Amore M, Mangin JF, Martino M. Dialogues in Clinical Neuroscience. 2026.
2. Yeh CH, Chen JR, Chao YP, Wu CT, Chou TL, Gau SSF, Ni HC, Lin HY, 2026. “White matter alterations linked to social cognitive improvements following theta burst stimulation of the right inferior frontal gyrus in autism.” NeuroImage: Clinical; 49: 103948.
3. Wei YC, Kung YC, Lin CP, Chen CK, Lin C, Tseng RY, Chen YL, Huang WY, Chen PY, Chong ST, Shyu YC, Yeh CH*, 2024. “White matter alterations and their associations with biomarkers and behavior in subjective cognitive decline individuals: a fixel-based analysis.” Behavioral and Brain Functions; 20: 12.
4. Ni HC, Chao YP, Tseng RY, Wu CT, Cocchi L, Chou TL, Chen RS, Gau SSF, Yeh CH*, Lin HY, 2023. “Lack of effects of four-week theta burst stimulation on white matter macro/microstructure in children and adolescents with autism.” NeuroImage: Clinical; 37: 103324.
5. Yeh CH, Tseng RY, Ni HC, Cocchi L, Chang JC, Hsu MY, Tu EN, Wu YY, Chou TL, Gau SSF, Lin HY, 2022. “White matter microstructural and morphometric alterations in autism: Implications for intellectual capabilities.” Molecular Autism. 13: 21.
6. Koh CL+, Yeh CH+, Liang X, Vidyasagar R, Seitz RJ, Nilsson M, Connelly A, Carey LM, 2021. “Structural connectivity remote from lesions correlates with somatosensory outcome post-stroke.” Stroke. 52: 2910-20. (+Joint first-author)
7. Yeh CH*, Jones DK, Liang X, Descoteaux M, Connelly A, 2021. “Mapping structural connectivity using diffusion MRI: challenges and opportunities.” J Magn Reson Imaging. 53: 1666-1682.
Abstract：
Narcolepsy is a disabling neurological disorder characterised by impaired sleep-wake regulation. Previous diffusion MRI studies have identified white matter differences beyond the hypothalamus, providing a rationale for investigating the distributed structural pathways that may contribute to the clinical manifestations of narcolepsy. Diffusion MRI offers a non-invasive means of probing white matter organisation in vivo. This presentation will discuss a methodological framework for investigating white matter microstructure in narcolepsy, with emphasis on quantitative diffusion MRI and fibre-specific assessment. The broader aim is to clarify how distributed white matter alterations relate to disrupted sleep-wake regulation and variation in clinical presentation. By connecting microstructural imaging with clinical phenotypes, this work may advance understanding of narcolepsy and inform future studies of disease mechanisms and treatment-related changes.
2026年會：