講師資料
Talks:
OSA Surgery in the GLP-1 Era: Challenge, Opportunity, and Reinvention
大減重藥物時代:睡眠外科的挑戰、機會與重新定位
Name:
徐英碩(Ying-Shuo Hsu)
Position:
1. Attending Physician, Department of Otolaryngology
2. Researcher, Institute of Brain Science
3. Vice Chair, Sleep Surgery Committee
Affiliation:
1. Shin Kong Wu Ho-Su Memorial Hospital
2. National Yang Ming Chiao Tung University
3. Taiwan Society of Sleep Medicine
Email:
Photo:
Research Interests:
睡眠外科
睡眠呼吸中止症
耳鼻喉科學
Selected Publications:
1. Hsu YS, Ke YK, Kuo TBJ, et al. Expiratory Velopharyngeal Obstruction: Sleep Endoscopy-Guided Treatment Strategies to Prevent Oral Breathing During Sleep. Otolaryngol Head Neck Surg. 2024;171(5):1591-1600. doi:10.1002/ohn.902
2. Chung SL, Chen CT, Wang CT, et al. Weakly Supervised Learning Applied for Airway Patency Identification in Drug-Induced Sleep Endoscopy Videos. In: 2024 International Joint Conference on Neural Networks (IJCNN). IEEE; 2024:1-8. doi:10.1109/IJCNN60899.2024.10650409
3. Lin HC, Wang CH, Kuo TBJ, et al. Upper Airway Surgery or Weight Control? Modified Drug-Induced Sleep Endoscopy for Obstructive Sleep Apnea. Otolaryngol Head Neck Surg. 2023;169(5):1345-1355. doi:10.1002/ohn.364
4. Shih HW, Chen YL, Lin HC, et al. Potential Treatments for Epiglottic Collapse in Obstructive Sleep Apnea: How Modified Drug-Induced Sleep Endoscopy Help? Otolaryngol Head Neck Surg. Published online November 23, 2023. doi:10.1002/ohn.572
5. Chiu FH, Chang Y, Liao WW, et al. Post-Operative Sleep Endoscopy with Target-Controlled Infusion After Palatopharyngoplasty for Obstructive Sleep Apnea: Anatomical and Polysomnographic Outcomes. Nat Sci Sleep. 2021;13:1181-1193. doi:10.2147/NSS.S311702
Abstract:
GLP-1 受體促效劑及 GIP/GLP-1 雙重受體促效劑的發展,正在改變肥胖合併阻塞性睡眠呼吸中止症(OSA)的治療選擇。SURMOUNT-OSA 試驗顯示,tirzepatide 治療 52 週可顯著改善體重、呼吸中止低通氣指數(AHI)與缺氧負荷。然而,減重後仍可能存在結構性阻塞與殘餘 OSA。睡眠外科面臨的核心問題,是如何重新界定手術適應症、介入時機及其在整合治療中的角色。
本演講將從睡眠外科醫師的臨床實務出發,探討「先減重還是先手術」,以及如何結合藥物、正壓呼吸器(PAP)、口內裝置與手術。治療順序應依疾病嚴重度、夜間低血氧、日間嗜睡、肥胖程度、解剖構造及 PAP 耐受性個別規畫。對需要即時控制呼吸事件的病人,應同步處理氣道阻塞與體重代謝問題;等待睡眠內視鏡(DISE)期間,則可安排體重管理、PAP 適應與共病控制。透過介入式 DISE 的動態模擬,辨識殘餘阻塞及非手術方案的反應,並在明顯減重後重新評估睡眠檢查與手術需求。
在手術策略上,將討論由組織切除轉向氣道重建與穩定化,以及術前減重、術後體重維持和組合治療提升長期療效的可能性與證據限制。另以台灣門診情境,分析藥費與保險誘因、長期停留於起始劑量、DISE 等待期及跨專科協作等實務障礙,並納入肌肉保護與麻醉前用藥風險評估。睡眠外科醫師的重新定位,是以解剖評估為基礎,整合體重、代謝與氣道治療,依客觀睡眠檢查追蹤成效,建立分階段且可持續的個人化照護。
2026年會: