講師資料
Talks:
A Preliminary Longitudinal 18F-FDG PET Study of Cerebral Glucose Metabolism in Narcolepsy
嗜睡症大腦葡萄糖代謝影像之初步研究探討
Name:
蕭穎聰(Ing-Tsung Hsiao)
Position:
Professor
Affiliation:
Department of Medical Imaging & Radiological Sciences
Chang Gung University,
Email:
Photo:
Research Interests:
1. Medical Image processing and analysis
2. Neuroimaging for neurodegenerative diseases including AD and PD
3. Biomarker development in PET Imaging
4. Tomographic Image Reconstruction
5. Applications of Artificial Intelligence to Medical Imaging
Selected Publications:
1. JL Hsu, SY Huang, HC Wu, KJ Lin, KL Huang, CC Huang, SY Kim, IT Hsiao* (2026, May). A clinically feasible framework to estimate tau pathology and clinical–biological discordance in the Alzheimer’s disease spectrum. Alzheimer's Research & Therapy.
2. SY Huang, KJ Lin, GU Hung, IT Hsiao* (2025, Dec.). Updates of nuclear medicine imaging in neurodegenerative disorders. Journal of the Formosan Medical Association. doi: https://doi.org/10.1016/j.jfma.2025.11.032
3. HC Lin, KL Huang, SH Chen, TY Ho, CC Huang, JL Hsu, CC Chang, KJ Lin, IT Hsiao* (2025, Oct). Visual interpretation of [18F] Florzolotau Tau-PET imaging for differentiating alzheimer’s disease and progressive supranuclear palsy. Eur J Nuc Med Molecular Imaging. doi: 10.1007/s00259-025-07539-x
4. IT Hsiao, KJ Lin, CC Chang, HM Huang (2025, Oct). Classification of HC, MCI, and AD Based on CT Using Deep Learning. J Med Biol Engi, 45:766-772.
5. SY Huang, KJ Lin, ZJ Lyu, IT Hsiao* (2025, Aug). The Development of an Automatic Amyloid PET Quantification (AmPQ) Software with MR-based and MR-free Spatial Normalization. Journal of Medical and Biological Engineering, 45:492-501.
6. Li C-H, Fan S-P, Shih M-C, Weng YH, Chen TF, Cheng MF, Kuo MC, Peng PL, Higuchi M, Hsiao IT*, Lin KJ*, Lin CH*, Subcortical tau burden correlates with regional brain atrophy and plasma markers in four-repeat tauopathy parkinsonism. Journal of Parkinson’s Disease. Feb 2025;15(1):214-226. doi:10.1177/1877718X241298192
7. KL Huang#, IT Hsiao#, CW Huang, CG Huang, HI Chang, SH Huang, KJ Lin, MC Ma, CC Huang, CC Chang, The Taiwan‐ADNI workflow toward integrating plasma p‐tau217 into prediction models for the risk of Alzheimer's disease and tau burden, Alzheimer's & Dementia, 2025, 21(1), 10.1002/alz.14297.
8. Chin WC, Huang SY, Liu FY, Wang CH, Tang I, Hsiao IT*, Huang YS. The Application of Machine Learning on Brain Imaging Features of Different Narcolepsy Subtypes. Sleep. 2024 Jan 6
Abstract:
Previous 18F-FDG PET studies have demonstrated altered cerebral glucose metabolism in patients with narcolepsy, including distinct metabolic patterns between narcolepsy type 1 (NT1) and type 2 (NT2). However, the longitudinal evolution of these metabolic alterations remains unclear. This preliminary study aims to investigate changes in cerebral glucose metabolism over time using serial 18F-FDG PET imaging in patients with narcolepsy. Within-subject metabolic changes will be evaluated using regional and voxel-based analyses and explored in relation to clinical characteristics. This longitudinal approach may clarify whether metabolic abnormalities in narcolepsy represent stable disease-related features or dynamic changes associated with disease course, treatment, or neurobiological development.
2026年會: