Obstructive sleep apnea (OSA) is a prevalent sleep disorder that has been associated with various systemic health complications, including neurodegenerative conditions like Alzheimer's and Parkinson's disease. Interestingly, recent studies also point to the possibility that treating OSA could have a positive impact on these neurodegenerative conditions. Uvulopalatopharyngoplasty (UPPP) is a surgical intervention commonly employed to manage OSA. However, the influence of UPPP on neurodegenerative biomarkers remains underexplored. This talk aims to investigate and discuss the changes in neurodegenerative biomarkers in patients with sleep apnea before and after undergoing UPPP surgery.