Disruptions of normal sleep may disturb the balance of psycho-physical health; therefore, sleep disorders may interfere with the homeostasis of hormone levels, mood, and body weight. Current evidence supported a close relationship between gut microbiota and sleep disorders. The gut microbiota affects its host in many ways; in contrast, sleep disorders can alter microbiota composition and cause dysbiosis. These directional relationships between gut microbiota and sleep disorders may result in metabolic disorders, mood disorders, and other complications. In this talk, we will explore what is present in the literature on the link between gut microbiota and sleep disorders in humans.