Restless legs syndrome is a circadian rhythm related and sensorimotor disorder. The diagnostic criteria has been established by IRLSSG as follows: an urge to move, unpleasant sensation when rest, improving sensory symptoms after movement , and deterioration in the evening or night. The current pathogenesis of RLS is presumed as dopaminergic theory, and brain iron deficiency. We will discuss the latest concept of the syndrome especially the pathogenesis, comorbidities and associated diseases burden. Additionally, the relationship of RLS and epilepsy will be emphasized separately.